{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:04:49Z","timestamp":1715558689326},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg\/kg i.p. or 1 mg\/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg\/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.<\/jats:p>","DOI":"10.1161\/01.str.20.3.362","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"362-366","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of a new thyrotropin-releasing hormone derivative on behavioral changes after focal cerebral ischemia in rats."],"prefix":"10.1161","volume":"20","author":[{"given":"M","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kirino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.20.3.362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:45:07Z","timestamp":1715550307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.20.3.362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1161\/01.STR.20.3.362"],"URL":"https:\/\/doi.org\/10.1161\/01.str.20.3.362","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]},"assertion":[{"value":"1989-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}