{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:40:51Z","timestamp":1769514051156,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>We subjected nine dogs with severe granulocytopenia 4 days after the administration of mechlorethamine to 1 hour of cerebral ischemia induced by the controlled, incremental injection of air into the internal carotid artery. Cortical somatosensory evoked responses and cerebral blood flow determined by [14C]iodoantipyrine autoradiography were compared with those of six control dogs that had received mechlorethamine 1 day previously and were not yet granulocytopenic. Eleven additional control dogs received no mechlorethamine but had identical ischemic insults and were followed for 4 hours after ischemia. Both control groups had identical evoked response outcomes after 1 hour of recovery from ischemia. Granulocytopenic dogs had improved evoked response recoveries compared with either control group after 1 hour of recovery. No areas of very low blood flow were observed 1 hour after ischemia in the granulocytopenic dogs, but three of five dogs in the control group receiving mechlorethamine had such areas.<\/jats:p>","DOI":"10.1161\/01.str.20.3.390","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["Influence of granulocytopenia on canine cerebral ischemia induced by air embolism."],"prefix":"10.1161","volume":"20","author":[{"given":"A J","family":"Dutka","sequence":"first","affiliation":[{"name":"Diving Medicine Department, Naval Medical Research Institute, Bethesda, Maryland 20814-5055."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Kochanek","sequence":"additional","affiliation":[{"name":"Diving Medicine Department, Naval Medical Research Institute, Bethesda, Maryland 20814-5055."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Hallenbeck","sequence":"additional","affiliation":[{"name":"Diving Medicine Department, Naval Medical Research Institute, Bethesda, Maryland 20814-5055."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.20.3.390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:45:28Z","timestamp":1715550328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.20.3.390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1161\/01.STR.20.3.390"],"URL":"https:\/\/doi.org\/10.1161\/01.str.20.3.390","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]},"assertion":[{"value":"1989-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}