{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:01:04Z","timestamp":1791140464362,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reduction in the severity of angiographic constriction of cerebral arteries. While basilar artery diameter after double experimental subarachnoid hemorrhage in a series of untreated dogs (n = 34) averaged 65% of baseline diameter, arterial diameter in dogs treated prophylactically (n = 18) with 6 mg\/kg\/day cyclosporine A and adjunct low-dose steroid averaged 80% of baseline diameter, for a mean reduction in the severity of chronic arterial constriction of 42%. More important than the average effect, however, is the statistical observation that this mean improvement was obtained primarily by a dramatic reduction in the incidence of severe cerebral vasospasm, the situation most likely to account for morbidity and mortality after aneurysmal rupture.<\/jats:p>","DOI":"10.1161\/01.str.21.1.133","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs."],"prefix":"10.1161","volume":"21","author":[{"given":"J W","family":"Peterson","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Hackett","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bun","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Teramura","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N T","family":"Zervas","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Neurosurgical Service, Boston 02114."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.21.1.133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:49:23Z","timestamp":1715550563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.21.1.133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1161\/01.STR.21.1.133"],"URL":"https:\/\/doi.org\/10.1161\/01.str.21.1.133","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]},"assertion":[{"value":"1990-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}