{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T07:51:46Z","timestamp":1725868306250},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>Fibrinolytic therapy may be effective in the treatment of ischemic stroke, and clinical trials are under way. We evaluated two fibrinolytic agents, an analogue of tissue plasminogen activator (Fb-Fb-CF, the catalytic fragment of the tissue plasminogen activator molecule with a prolonged serum half-life, n = 10) and streptokinase (n = 7), in a rabbit model of embolic stroke. Both agents were given 3 hours after stroke onset, a time relevant to the clinical setting. Fb-Fb-CF was significantly better (p less than 0.04) than saline (n = 7) in restoring blood flow to previously occluded intracranial arteries, but streptokinase was ineffective. Neither fibrinolytic agent was associated with a substantial risk for intracerebral hemorrhagic side effects. Our study demonstrates that Fb-Fb-CF can safely and effectively reperfuse rabbit intracranial arteries 3 hours after occlusion, while streptokinase does not.<\/jats:p>","DOI":"10.1161\/01.str.21.4.602","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"602-605","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model."],"prefix":"10.1161","volume":"21","author":[{"given":"D A","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, Worcester."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, Worcester."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, Worcester."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T W","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, Worcester."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, Worcester."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.21.4.602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:26:00Z","timestamp":1715549160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.21.4.602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1161\/01.STR.21.4.602"],"URL":"https:\/\/doi.org\/10.1161\/01.str.21.4.602","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]},"assertion":[{"value":"1990-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}