{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:38:43Z","timestamp":1759963123587},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>We report a new plasminogen disorder detected in a 29-year-old man with a cerebellar infarct. To our knowledge, plasminogen disorders have not been previously linked with stroke.<\/jats:p>\n          <jats:p>Tests for well-recognized causes of stroke were negative. However, a screening hypercoagulation profile indicated low functional levels of plasminogen activity. Immunologic plasminogen (Laurell technique) was 64% of normal (normal level, 80-130%). The rate of plasmin generation induced by adding urokinase to plasma was also low. Plasminogen activator, free protease, and alpha 2-plasmin inhibitor levels were normal. Family studies detected a similar plasminogen abnormality in the patient's mother and 9-year-old son, both of whom are asymptomatic.<\/jats:p>\n          <jats:p>Our patient shows a congenital, heterozygous, functionally abnormal plasminogen. Although the exact relationship to stroke is unclear, we suggest screening young patients with unexplained stroke for plasminogen defects using commercially available assay systems.<\/jats:p>","DOI":"10.1161\/01.str.22.12.1598","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1598-1602","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Stroke in a young adult with familial plasminogen disorder."],"prefix":"10.1161","volume":"22","author":[{"given":"A J","family":"Furlan","sequence":"first","affiliation":[{"name":"Department of Neurology, Cleveland Clinic Foundation, OH 44106."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F V","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland Clinic Foundation, OH 44106."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Craciun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland Clinic Foundation, OH 44106."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Wohl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland Clinic Foundation, OH 44106."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.22.12.1598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:01:40Z","timestamp":1715551300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.22.12.1598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1161\/01.STR.22.12.1598"],"URL":"https:\/\/doi.org\/10.1161\/01.str.22.12.1598","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]},"assertion":[{"value":"1991-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}