{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:31:28Z","timestamp":1761708688562},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>We used 31P nuclear magnetic resonance spectroscopy to study the cerebral metabolic function of eight patients with severe postischemic anoxic encephalopathy secondary to cardiac arrest. Spectroscopy was performed at 18 +\/- 13 and 64 +\/- 20 hours after resuscitation. Glasgow Coma Scale scores at the time of initial and repeat spectroscopy were 3.6 +\/- 1.2 and 3.5 +\/- 1.2, respectively. In those patients whose spectra were of adequate quality to monitor pH, all demonstrated tissue alkalosis in at least one brain region. The mean brain pH at initial spectroscopy was 7.14 +\/- 0.09 and was significantly alkalotic when compared with age- and sex-matched normal controls (pH = 6.98 +\/- 0.04, p less than 0.0001). Five of the eight patients showed at least one region of persistent alkalosis at repeat spectroscopy, whereas one patient demonstrated severe acidosis with a pH of 6.42. Spectra demonstrated marked metabolic heterogeneity, ranging from normal in appearance to complete obliteration of all high-energy phosphates with only inorganic phosphate remaining.<\/jats:p>","DOI":"10.1161\/01.str.22.4.462","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"462-468","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Nuclear magnetic resonance spectroscopy study of human brain after cardiac resuscitation."],"prefix":"10.1161","volume":"22","author":[{"given":"G B","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Paradis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Helpern","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.22.4.462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:39:52Z","timestamp":1715553592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.22.4.462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["10.1161\/01.STR.22.4.462"],"URL":"https:\/\/doi.org\/10.1161\/01.str.22.4.462","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]},"assertion":[{"value":"1991-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}