{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:17:58Z","timestamp":1780532278742,"version":"3.54.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>Excitatory amino acids and their receptors are involved in mediating ischemic neuronal damage. The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective, hypothermic, and motor deficit effects of the sigma-agonist SKF 10,047 and the N-methyl-D-aspartate antagonist MK-801.<\/jats:p>\n          <jats:p>Neuroprotective effects were compared using an in vitro ischemia model of cultured rat cerebellar granule cells and the gerbil model of global brain ischemia induced by 5 minutes of bilateral carotid artery occlusion followed by 7 days of reperfusion.<\/jats:p>\n          <jats:p>In vitro, (+)MK-801 protected against 100 microM glutamate with a 50% protective concentration of 30 nM, followed by (-)MK-801 (150 nM), cyclazocine (0.5 microM), (+)SKF 10,047 (3.3 microM), pentazocine (5 microM), and (-)SKF 10,047 (10 microM). In vivo, (+)SKF 10,047 pretreatment (60 mg\/kg) or multiple postischemic treatments provided neuroprotection comparable with MK-801 pretreatment (10 mg\/kg). When ischemic animals were administered the multiple dosing regimen of (+)SKF 10,047, no hypothermic effect was noted in the temporalis muscle over 4 hours' postischemia. Motor deficits monitored by a swing grid test showed that 50% recovery from (+)SKF 10,047 was 5.5 times faster than recovery from MK-801.<\/jats:p>\n          <jats:p>These results are the first to report a hypothermia-free, in vivo neuroprotective effect of (+)SKF 10,047, a prototypical drug of the sigma-agonist class.<\/jats:p>","DOI":"10.1161\/01.str.23.3.414","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia."],"prefix":"10.1161","volume":"23","author":[{"given":"P G","family":"Lysko","sequence":"first","affiliation":[{"name":"Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T L","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.23.3.414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:28:03Z","timestamp":1715552883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.23.3.414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1161\/01.STR.23.3.414"],"URL":"https:\/\/doi.org\/10.1161\/01.str.23.3.414","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]},"assertion":[{"value":"1992-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}