{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:02:10Z","timestamp":1783350130633,"version":"3.54.6"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>Serial changes of anti-platelet-aggregating activity in the endothelial cells after experimental subarachnoid hemorrhage were studied in 30 feline two-hemorrhage models.<\/jats:p>\n          <jats:p>One hour or 2, 4, 7, or 14 days after mimic subarachnoid hemorrhage, ADP (40 mg\/kg) was infused into the basilar artery via the right vertebral artery to activate circulating platelets. Immediately after ADP infusion, the basilar artery was fixed by intra-arterial perfusion with 1.5% glutaraldehyde in 0.1 mol\/L phosphate buffer and was removed. The luminal surface was examined under a scanning electron microscope.<\/jats:p>\n          <jats:p>One hour after subarachnoid hemorrhage, no platelets adhered or aggregated on the luminal surface. However, 4 to 7 days after subarachnoid hemorrhage, many platelets were observed adhering or aggregating on the luminal surface.<\/jats:p>\n          <jats:p>These findings suggest the impairment of anti-platelet-aggregating activity of endothelial cells after subarachnoid hemorrhage. This impairment may be involved in inducing cerebral ischemia during cerebral vasospasm by causing platelet adhesion and aggregation.<\/jats:p>","DOI":"10.1161\/01.str.24.10.1541","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1541-1545","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Impairment of anti-platelet-aggregating activity of endothelial cells after experimental subarachnoid hemorrhage."],"prefix":"10.1161","volume":"24","author":[{"given":"H","family":"Ohkuma","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hirosaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ogane","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hirosaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hirosaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hirosaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hirosaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.10.1541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:07:41Z","timestamp":1715551661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.10.1541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1161\/01.STR.24.10.1541"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.10.1541","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]},"assertion":[{"value":"1993-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}