{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:02:18Z","timestamp":1745748138116},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>Deficiency of the free fraction of protein S has been associated with arterial or venous stroke. The pathogenesis of vascular occlusion in patients with protein S deficiency is not known. We present two cases of cerebral infarction and deficiency of protein S in which the subjects had progressive intracranial occlusions.<\/jats:p>\n          <jats:p>A 16-year-old girl was admitted because of left brain stem infarction and protein S deficiency. Cerebral angiography disclosed stenosis of the right intracranial vertebral artery and occlusion of the left posterior cerebral artery. A second angiogram performed 18 months later disclosed occlusion of the right vertebral intracranial artery. In the second case, a 17-year-old girl was admitted because of left hemispheric cerebral infarction and protein S deficiency. Cerebral angiography showed stenosis of the left anterior cerebral artery, left supraclinoid internal artery, and left middle cerebral artery. A second cerebral angiogram performed 5 months later disclosed occlusion of the left anterior cerebral artery and poor hemispheric perfusion through the left middle cerebral artery.<\/jats:p>\n          <jats:p>Based on our cases, we postulate that some patients with prothrombotic states may develop progressive intracranial arterial occlusions, possibly secondary to a permanent thrombogenic stimulus. We suggest routinely searching for prothrombotic states in young patients with intracranial occlusion, especially if the occlusion is progressive and other causes are not obvious.<\/jats:p>","DOI":"10.1161\/01.str.24.11.1752","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1752-1756","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Progressive intracranial occlusive disease associated with deficiency of protein S. Report of two cases."],"prefix":"10.1161","volume":"24","author":[{"given":"F","family":"Barinagarrementeria","sequence":"first","affiliation":[{"name":"Stroke Clinic, Instituto Nacional de Neurolog\u00eda Neurocirug\u00eda, Tlalpan, M\u00e9xico, D.F."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cant\u00fa Brito","sequence":"additional","affiliation":[{"name":"Stroke Clinic, Instituto Nacional de Neurolog\u00eda Neurocirug\u00eda, Tlalpan, M\u00e9xico, D.F."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Izaguirre","sequence":"additional","affiliation":[{"name":"Stroke Clinic, Instituto Nacional de Neurolog\u00eda Neurocirug\u00eda, Tlalpan, M\u00e9xico, D.F."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Stroke Clinic, Instituto Nacional de Neurolog\u00eda Neurocirug\u00eda, Tlalpan, M\u00e9xico, D.F."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.11.1752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:23:58Z","timestamp":1715552638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.11.1752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1161\/01.STR.24.11.1752"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.11.1752","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]},"assertion":[{"value":"1993-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}