{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:17:25Z","timestamp":1770283045403,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>An animal model has been developed to elucidate the pathological changes in brain cytoskeletal proteins during chronic hypoperfusion.<\/jats:p>\n          <jats:p>Newly designed coiled clips were placed around both carotid arteries of Mongolian gerbils (n = 10) to cause stenosis without occlusion. Those gerbils showing impaired learning ability by the passive avoidance paradigm were killed for neuropathologic study after 12 weeks.<\/jats:p>\n          <jats:p>The brains showed ventricular dilatation, cortical atrophy, and rarefaction of the white matter. Immunoreactivity to anti-microtubule-associated protein 2 antibody in the cerebral cortex and the hippocampus was diminished, indicating dendritic changes of neurons. In the thalamic axonal regions, staining with anti-neurofilament 200K protein antibody was increased, suggesting increased amounts of neurofilament proteins or increased phosphorylation of the protein. Increased immunoreactivity to anti-glial fibrillary acidic protein antibody was observed in a wedge-shaped configuration, corresponding to the border zone of perfusion by small vessels.<\/jats:p>\n          <jats:p>These findings suggest that changes in the cytoskeletal proteins in dendrites, axons, and glial cells may cause neuronal death under conditions of chronic cerebral hypoperfusion.<\/jats:p>","DOI":"10.1161\/01.str.24.2.259","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Neuropathologic changes in the gerbil brain after chronic hypoperfusion."],"prefix":"10.1161","volume":"24","author":[{"given":"T","family":"Kudo","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Osaka University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Osaka University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tanimukai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Osaka University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Osaka University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.2.259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:27:34Z","timestamp":1715552854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.2.259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1161\/01.STR.24.2.259"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.2.259","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]},"assertion":[{"value":"1993-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}