{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:34:06Z","timestamp":1789821246210,"version":"4.0.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>Experiments were designed to determine the effect of subarachnoid hemorrhage on endothelium-dependent relaxations in small arteries of the brain stem. A \"double-hemorrhage\" canine model of the disease was used, and the presence of vasospasm in the basilar artery was confirmed by angiography.<\/jats:p>\n          <jats:p>Secondary branches of both untreated basilar arteries (inner diameter, 324 +\/- 11 microns; n = 12) and arteries exposed to subarachnoid hemorrhage for 7 days (inner diameter, 328 +\/- 12 microns; n = 12) were dissected and mounted on glass microcannulas in organ chambers. Changes in the intraluminal diameter of pressurized arteries were measured using a video dimension analyzer.<\/jats:p>\n          <jats:p>In untreated arteries, 10(-11) to 10(-7) M vasopressin, 10(-10) to 10(-6) M bradykinin, and 10(-9) to 10(-6) M calcium ionophore A23187 caused endothelium-dependent relaxations. At 10(-6) and 3 x 10(-4) M the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) abolished relaxations to vasopressin and produced small but significant rightward shifts of the concentration-response curves to bradykinin and A23187. At 10(-3) M L-arginine prevented the inhibitory effect of L-NAME. Subarachnoid hemorrhage abolished relaxations to vasopressin but did not affect relaxations to bradykinin or A23187.<\/jats:p>\n          <jats:p>These studies suggest that in small arteries of the brain stem vasopressin causes relaxations by activation of the endothelial L-arginine pathway. This mechanism of relaxation is selectively inhibited by subarachnoid hemorrhage. Preservation of endothelium-dependent relaxations to bradykinin and A23187 is consistent with the concept that small arteries are resistant to vasospasm after subarachnoid hemorrhage.<\/jats:p>","DOI":"10.1161\/01.str.24.3.392","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"392-399","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Subarachnoid hemorrhage and endothelial L-arginine pathway in small brain stem arteries in dogs."],"prefix":"10.1161","volume":"24","author":[{"given":"Z S","family":"Katusi\u0107","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Milde","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cosentino","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B S","family":"Mitrovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.3.392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:08:38Z","timestamp":1715551718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.3.392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1161\/01.STR.24.3.392"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.3.392","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]},"assertion":[{"value":"1993-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}