{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:09:41Z","timestamp":1790413781222,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>The aim of this randomized double-blind, placebo-controlled trial was to evaluate whether neurological deficits could be prevented with low-dose acetylsalicylic acid (ASA) as an adjunct to carotid endarterectomy.<\/jats:p>\n          <jats:p>A total of 232 patients were randomized to two groups, 75 mg\/d ASA starting preoperatively and continued for 6 months (n = 117) or placebo (identical tablets) (n = 115). The patients were followed up regularly for 1 year.<\/jats:p>\n          <jats:p>The groups were well matched regarding laboratory data and indication for operation. The number of patients with intraoperative or postoperative stroke without complete recovery within 1 week were 0 and 2 at 30 days and 6 months, respectively, in the ASA group, compared with 7 and 11 in the placebo group (P = .01). Including all neurological events within 6 months, this was found in 15 patients in the ASA group compared with 24 in the placebo group (P = .12). Mortality was 0.8% and 3.4% at 30 days and 6 months, respectively, in the ASA group. In the placebo group, the corresponding figures were 4.3% and 6.0%, respectively (P = .12). The intraoperative bleeding did not differ between the groups nor did the number of reoperations due to bleeding or other complications related to pharmacology.<\/jats:p>\n          <jats:p>This study indicates that low-dose ASA (75 mg\/d) reduces the number of postoperative strokes without complete recovery within 1 week. Overall neurological events are insignificantly reduced, as also mortality. The use of low-dose ASA (75 mg) seems safe and effective in reducing cerebrovascular events after carotid endarterectomy.<\/jats:p>","DOI":"10.1161\/01.str.24.8.1125","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1125-1128","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":141,"title":["Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? A double-blind, placebo-controlled randomized trial."],"prefix":"10.1161","volume":"24","author":[{"given":"B","family":"Lindblad","sequence":"first","affiliation":[{"name":"Department of Surgery, Malm\u00f6 General Hospital, Lund University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N H","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Malm\u00f6 General Hospital, Lund University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Takolander","sequence":"additional","affiliation":[{"name":"Department of Surgery, Malm\u00f6 General Hospital, Lund University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bergqvist","sequence":"additional","affiliation":[{"name":"Department of Surgery, Malm\u00f6 General Hospital, Lund University, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.8.1125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:12:08Z","timestamp":1715551928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.8.1125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1161\/01.STR.24.8.1125"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.8.1125","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]},"assertion":[{"value":"1993-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}