{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:53:21Z","timestamp":1773302001970,"version":"3.50.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>Transcranial color duplex sonographic examinations in children and adolescents without cerebrovascular disease were evaluated retrospectively. Flow velocities and waveform parameters were determined and their side-to-side differences and age dependence analyzed and, finally, compared with analogous data of a previously described group of healthy adults.<\/jats:p>\n          <jats:p>With a 2.0-MHz sector transducer of a computed sonographic system, the anterior, middle, and posterior cerebral arteries were examined in 64 children and adolescents between 1.5 and 17.5 years of age. Angle-corrected systolic peak, end-diastolic maximum, time-averaged, and time-averaged maximum velocities, and the resistance, pulsatility, and spectral broadening indexes were determined in all vessels.<\/jats:p>\n          <jats:p>Mean +\/- SD values for time-averaged maximum velocity (and time-averaged velocity) were 92.2 +\/- 13.0, 79.9 +\/- 17.7, and 63.9 +\/- 13.6 (55.3 +\/- 11.7, 40.4 +\/- 10.4, and 34.2 +\/- 9.2) cm\/s, respectively, in the middle, anterior, and posterior cerebral arteries in children under 10 years of age; values were 83.2 +\/- 11.9, 69.4 +\/- 13.8, and 55.6 +\/- 10.1 (50.8 +\/- 9.0, 39.9 +\/- 10.5, and 33.1 +\/- 6.3) cm\/s, respectively, in children 10 years of age and older. Time-averaged maximum velocity decreased significantly with age in all vessels (P &lt; .001). Although time-averaged velocity did not change significantly during childhood and adolescence, a clear decline occurred from adolescence to adulthood (P &lt; .0001 in the middle and posterior cerebral arteries; P &lt; .01 in the anterior cerebral artery). The spectral broadening index decreased significantly from childhood to adolescence in the anterior and posterior cerebral arteries (P &lt; .0001). The resistance and pulsatility indexes remained stable throughout childhood.<\/jats:p>\n          <jats:p>Transcranial color duplex sonography allows angle-corrected measurements of \"true\" flow velocities in basal cerebral arteries. Additional determination of time-averaged velocity permits more detailed evaluation of flow characteristics for all age groups. The transcranial color duplex technique may provide deeper insights on normal cerebral perfusion and its disorders.<\/jats:p>","DOI":"10.1161\/01.str.24.9.1305","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1305-1309","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Transcranial color duplex sonography in childhood and adolescence. Age dependence of flow velocities and waveform parameters."],"prefix":"10.1161","volume":"24","author":[{"given":"M","family":"Sch\u00f6ning","sequence":"first","affiliation":[{"name":"Division of Neuropediatrics, Children's Hospital of the University, T\u00fcbingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Staab","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Children's Hospital of the University, T\u00fcbingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Walter","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Children's Hospital of the University, T\u00fcbingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Niemann","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Children's Hospital of the University, T\u00fcbingen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.24.9.1305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:27:01Z","timestamp":1715552821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.24.9.1305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1161\/01.STR.24.9.1305"],"URL":"https:\/\/doi.org\/10.1161\/01.str.24.9.1305","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]},"assertion":[{"value":"1993-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}