{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:25:30Z","timestamp":1793175930803,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1994,10]]},"abstract":"The aim of this study was to determine whether dementia after stroke adversely influences long-term survival.<\/jats:p>\n Subjects were 251 patients > or = 60 years of age with ischemic stroke who were given neurological, neuropsychological, and functional examinations 3 months after hospitalization and were followed up prospectively. Using criteria modified from the Diagnostic and Statistical Manual of Mental Disorders-III-R, dementia was found in 66 (26.3%) patients at the 3-month baseline examination. Life-table methods were used to estimate mortality rates in the groups with and without dementia after 1 to 5 years of follow-up, Kaplan-Meier curves to estimate the cumulative proportion surviving with and without dementia, and Cox proportional-hazards analysis to compute the relative risk of mortality associated with dementia at baseline, after adjusting for other potential predictors of stroke mortality.<\/jats:p>\n The mortality rate was 19.8 deaths per 100 person-years with dementia compared with 6.9 deaths per 100 person-years without dementia. The cumulative proportion surviving after a median follow-up of 58.6 months was 38.9 +\/- 0.08% for those with dementia and 74.5 +\/- 0.04% for those without dementia. The relative risk associated with dementia was 3.11 (95% confidence interval, 1.79 to 5.41) after adjusting for the effects of demographic factors, cardiac disease, severity of stroke (Barthel Index), stroke type (lacunar versus nonlacunar), and recurrent stroke (examined as a time-dependent variable). When the Mini-Mental State Examination score at baseline was examined instead of the diagnosis of dementia, the results of the model were similar.<\/jats:p>\n Our study is the first to demonstrate that dementia or cognitive impairment adversely influences long-term survival after stroke, even after adjusting for other commonly accepted predictors of stroke mortality. Impairment in intellectual function after stroke, independent of physical disability, has a significant impact on prognosis. Both cognitive and physical functions should be assessed in clinical studies of stroke outcome.<\/jats:p>","DOI":"10.1161\/01.str.25.10.1915","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1915-1919","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":128,"title":["Dementia after stroke is a predictor of long-term survival."],"prefix":"10.1161","volume":"25","author":[{"given":"T K","family":"Tatemichi","sequence":"first","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bagiella","sequence":"additional","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pirro","sequence":"additional","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L K","family":"Hanzawa","sequence":"additional","affiliation":[{"name":"Department of Neurology (Stroke and Aging Research Project), Columbia University, College of Physicians and Surgeons, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.25.10.1915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:04:58Z","timestamp":1715551498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.25.10.1915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1161\/01.STR.25.10.1915"],"URL":"https:\/\/doi.org\/10.1161\/01.str.25.10.1915","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]},"assertion":[{"value":"1994-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}