{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:52:30Z","timestamp":1762271550207},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>Calcitonin gene-related peptide is an endogenous vasodilating neuropeptide with a dense concentration in the trigeminocerebrovascular system. It is hypothesized that depletion of this peptide contributes to delayed cerebral ischemia after subarachnoid hemorrhage and that an exogenous supply of calcitonin gene-related peptide will augment ischemic cerebral blood flow and reduce neuronal injury.<\/jats:p>\n          <jats:p>In this study we have investigated the effect of an intravenous infusion of calcitonin gene-related peptide (100 ng\/kg per minute), started 1 hour before and continued throughout 4 hours of focal cerebral ischemia, on cerebral blood flow and the volume of brain injury in a rat model of middle cerebral artery occlusion.<\/jats:p>\n          <jats:p>Calcitonin gene-related peptide produces a significant improvement in ischemic cerebral blood flow (32 +\/- 2 compared with 13 +\/- 2 mL\/100 g per minute in the controls; t = 6.92, P &lt; .0001) with a concomitant reduction in the volume of ischemic brain injury (102 +\/- 22 compared with 234 +\/- 19 mm3; t = 4.47, P &lt; .001).<\/jats:p>\n          <jats:p>These findings lend support for the potential use of this peptide in the prophylactic treatment of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.<\/jats:p>","DOI":"10.1161\/01.str.25.10.2055","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2055-2058","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Calcitonin gene-related peptide reduces brain injury in a rat model of focal cerebral ischemia."],"prefix":"10.1161","volume":"25","author":[{"given":"J P","family":"Holland","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience, St George's Hospital Medical School, Atkinson Morley's Hospital, Wimbledon, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S G","family":"Sydserff","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience, St George's Hospital Medical School, Atkinson Morley's Hospital, Wimbledon, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience, St George's Hospital Medical School, Atkinson Morley's Hospital, Wimbledon, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B A","family":"Bell","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience, St George's Hospital Medical School, Atkinson Morley's Hospital, Wimbledon, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.25.10.2055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:05:27Z","timestamp":1715551527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.25.10.2055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1161\/01.STR.25.10.2055"],"URL":"https:\/\/doi.org\/10.1161\/01.str.25.10.2055","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]},"assertion":[{"value":"1994-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}