{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:18:37Z","timestamp":1789373917004,"version":"build-2803163510"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:p>The aim of this study is to elucidate the effect of orthostatic hypotension on changes in cerebral blood flow.<\/jats:p>\n          <jats:p>Blood flow velocities of both the common carotid artery and vertebral artery were measured using duplex ultrasonography in 12 patients: 6 with familial amyloidotic polyneuropathy, 3 with Shy-Drager syndrome, 2 with pandysautonomia, and 1 with senile orthostatic hypotension. Simultaneously, peripheral blood flow was also evaluated by laser-Doppler flowmetry.<\/jats:p>\n          <jats:p>The patients showing dizziness or syncope when tilted to a 70 degrees upright position exhibited characteristic reverse flow at the end-diastolic phase on the Doppler flow image of both the common carotid and vertebral arteries, which was effectively treated by infusion of 2.5 micrograms\/min norepinephrine for 10 minutes. This end-diastolic reverse flow was not seen in any patients who did not have dizziness or syncope. After subjects were tilted from a supine to a 70 degrees upright position, decrease in the peripheral blood flow of the patients with orthostatic hypotension remained unchanged for at least 5 minutes, whereas that of control subjects was recovered within 2 minutes. However, no significant difference between the patients with and without clinical symptoms was observed.<\/jats:p>\n          <jats:p>These results suggest that detection of this specific echographic pattern may be quantitatively useful in examination of clinical symptoms accompanying orthostatic hypotension and that duplex ultrasonography may be a helpful tool to evaluate the effect of drugs used for controlling these clinical signs.<\/jats:p>","DOI":"10.1161\/01.str.25.12.2407","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2407-2411","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Detection of reverse flow by duplex ultrasonography in orthostatic hypotension."],"prefix":"10.1161","volume":"25","author":[{"given":"T","family":"Yonehara","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ando","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kimura","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Uchino","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ando","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kumamoto University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.25.12.2407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:11:37Z","timestamp":1715551897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.25.12.2407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1161\/01.STR.25.12.2407"],"URL":"https:\/\/doi.org\/10.1161\/01.str.25.12.2407","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]},"assertion":[{"value":"1994-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}