{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:59:33Z","timestamp":1758970773383},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>Cerebral vasoreactivity is an important indicator of the reserve capacity of the cerebral circulation. To make a quantitative analysis of cerebral vasoreactivity in individual major arterial territories, we evaluated the response to acetazolamide using three-dimensional time-of-flight magnetic resonance angiography.<\/jats:p>\n          <jats:p>We examined 10 healthy volunteers and 6 patients with unilateral stenosis of the middle cerebral artery by a 1.5-T superconducting magnetic resonance imaging system. After a baseline vascular image was obtained, each subject received 17 mg\/kg IV of acetazolamide; a second scan was performed 20 minutes later. Using a generally available personal computer and image analysis software, we measured the areas of the individual major arteries on collapsed axial vascular images and then calculated the vasoreactivity.<\/jats:p>\n          <jats:p>The average vasoreactivity of individual major cerebral arterial territories in the healthy volunteers was as follows: anterior cerebral artery complex, 33%; right middle cerebral artery, 71%; left middle cerebral artery, 74%; right posterior cerebral artery, 68%; and left posterior cerebral artery, 68%. In the patient group, the vasoreactivity of the stenotic middle cerebral arteries was significantly smaller than that of the nonstenotic arteries (P &lt; .05). In addition, the nonstenotic middle cerebral arteries showed significantly less vasoreactivity than the right arteries of the healthy volunteers (P &lt; .01).<\/jats:p>\n          <jats:p>Three-dimensional time-of-flight magnetic resonance angiography can be used to quantitatively evaluate acetazolamide-induced vasoreactivity in individual major cerebral arterial territories.<\/jats:p>","DOI":"10.1161\/01.str.25.9.1807","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1807-1811","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of cerebral vasoreactivity by three-dimensional time-of-flight magnetic resonance angiography."],"prefix":"10.1161","volume":"25","author":[{"given":"K","family":"Mandai","sequence":"first","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sueyoshi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nukada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Tsukaguchi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Osaka Rosai Hospital, Sakai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.25.9.1807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:16:25Z","timestamp":1715552185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.25.9.1807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1161\/01.STR.25.9.1807"],"URL":"https:\/\/doi.org\/10.1161\/01.str.25.9.1807","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]},"assertion":[{"value":"1994-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}