{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:15:24Z","timestamp":1791191724112,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>Cardiac arrest and resuscitation in immature piglets result in a delayed increase in blood-brain barrier permeability. We tested the hypothesis that pretreatment with oxygen radical scavengers reduces postischemic permeability.<\/jats:p>\n          <jats:p>Permeability was assessed by measuring the plasma-to-brain transfer coefficient of the small amino acid, alpha-aminoisobutyric acid, in 2- to 3-week-old anesthetized piglets. Three groups were studied: (1) a nonischemic time control group (n = 5), (2) an ischemia group (n = 8) pretreated with 5 mL of polyethylene glycol vehicle, and (3) an ischemia group (n = 8) pretreated with polyethylene glycol conjugated to superoxide dismutase (10,000 U\/kg) and to catalase (20,000 U\/kg). The ischemia protocol consisted of 8 minutes of ventricular fibrillation, 6 minutes of cardiopulmonary resuscitation, defibrillation, and 4 hours of spontaneous circulation.<\/jats:p>\n          <jats:p>The mean +\/- SEM of the transfer coefficient of alpha-aminoisobutyric acid in cerebrum was (in microL\/g per minute): 1.54 +\/- 0.37 in the nonischemic group, 2.04 +\/- 0.26 in the ischemia group treated with vehicle, and 1.29 +\/- 0.25 in the ischemia group treated with oxygen radical scavengers. Postischemic values with scavenger treatment were significantly lower than those with vehicle treatment in cerebrum, cerebellum, medulla and cervical spinal cord.<\/jats:p>\n          <jats:p>Pretreatment with oxygen radical scavengers reduces postischemic blood-brain barrier permeability by a small amino acid. These data are consistent with oxygen radical-mediated dysfunction of cerebral endothelium in a pediatric model of cardiopulmonary resuscitation.<\/jats:p>","DOI":"10.1161\/01.str.25.9.1830","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1830-1834","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Reduced blood-brain barrier permeability after cardiac arrest by conjugated superoxide dismutase and catalase in piglets."],"prefix":"10.1161","volume":"25","author":[{"given":"C L","family":"Schleien","sequence":"first","affiliation":[{"name":"Department of Anesthesiology\/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Eberle","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology\/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Shaffner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology\/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology\/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Traystman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology\/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.25.9.1830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:16:30Z","timestamp":1715552190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.25.9.1830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1161\/01.STR.25.9.1830"],"URL":"https:\/\/doi.org\/10.1161\/01.str.25.9.1830","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]},"assertion":[{"value":"1994-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}