{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:41:05Z","timestamp":1770979265024,"version":"3.50.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            The role of recent heavy drinking of alcohol as a risk factor for ischemic brain infarction is unclear. We investigated this problem in young adults, in whom even a thorough workup often fails to reveal any predisposing factor.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            This was a hospital-based case-control study comprising 75 consecutive subjects aged 16 to 40 years with first-ever ischemic brain infarction and 133 control subjects from the same hospital who were group-matched with the case patients for age, sex, day of the onset of symptoms, and acuteness of disease onset.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Multiple logistic regression analysis showed that alcohol intake exceeding 40 g of ethanol within the 24 hours preceding disease onset was a significant independent risk factor for brain infarction among both men (odds ratio [OR], 6.0; 95% confidence interval [CI], 1.8 to 20.3) and women (OR, 7.8; 95% CI, 1.0 to 60.8). Cigarette smoking was not found to be an independent risk factor in the model, whereas among men arterial hypertension was (OR, 6.2; 95% CI, 1.5 to 24.7).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            We conclude that very recent alcohol drinking, particularly drinking for intoxication, may trigger the onset of brain infarction in young adults and that there might be a variety of mechanisms behind this effect.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.1.40","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Recent Alcohol Consumption, Cigarette Smoking, and Cerebral Infarction in Young Adults"],"prefix":"10.1161","volume":"26","author":[{"given":"Matti","family":"Hillbom","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Haapaniemi","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Juvela","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Paloma\u0308ki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Numminen","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Kaste","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (H.P., M.K.) and Neurosurgery (S.J.), Helsinki University Hospital, and the Department of Neurology (M.H., H.H., H.N., Oulu University Hospital, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6785.1111"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804143181501"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.789"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90894-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.2.2305396"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3094199"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.9.1519278"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.5.8488517"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.6.3810710"},{"key":"e_1_3_3_10_2","first-page":"367","volume":"87","year":"1993","unstructured":"Fogelholm R, Murros K. 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