{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:41:42Z","timestamp":1767897702542,"version":"3.49.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Cerebral infarction is a known complication in patients with mitochondrial encephalomyopathies (MELAS, MERRF, Kearns-Sayre syndrome), but the etiology in the different types remains uncertain.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Description<\/jats:italic>\n            A 33-year-old woman who had suffered from ophthalmoplegia, bilateral ptosis, ataxia, retinitis pigmentosa, and epilepsy since childhood was diagnosed to have Kearns-Sayre syndrome. The diagnosis was confirmed by muscle biopsy when she was 17 years old. A pacemaker was implanted because of the occurrence of bradyarrhythmias when she was 24 years old. The patient was admitted to the hospital with left-sided hemiparesis of sudden onset due to right striatocapsular infarction. Results of Doppler sonography of the carotid arteries were normal; however, transesophageal echocardiography revealed a thrombus in the left atrial appendage.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Stroke in Kearns-Sayre syndrome is likely to be due to cardiac embolism. Anticoagulant therapy should be considered even for mild forms of cardiomyopathies leading to left ventricular dysfunction.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.10.1950","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1950-1952","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Evidence for Cardioembolic Stroke in a Case of Kearns-Sayre Syndrome"],"prefix":"10.1161","volume":"26","author":[{"given":"Christoph","family":"Kosinski","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (C.K., R.T.), Neuroradiology (M.M.), and Cardiology (H.L.), Technical University of Aachen (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mull","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.K., R.T.), Neuroradiology (M.M.), and Cardiology (H.L.), Technical University of Aachen (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Lethen","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.K., R.T.), Neuroradiology (M.M.), and Cardiology (H.L.), Technical University of Aachen (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"To\u0308pper","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (C.K., R.T.), Neuroradiology (M.M.), and Cardiology (H.L.), Technical University of Aachen (Germany)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160409"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.005523"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.4.3363584"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688185"},{"key":"e_1_3_1_5_2","unstructured":"DiMauro S Tonin P Servidei S. Metabolic myopathies. In: Handbook of Clinical Neurology. New York NY: Elsevier Science Publishers BV. 1992;62:479-523."},{"key":"e_1_3_1_6_2","first-page":"467","volume":"147","year":"1991","unstructured":"Rowland LP, Blake DM, Hirano M, DiMauro S, Schon EA, Hays AP, DeVivo DC. Clinical syndromes associated with ragged red fibers. Rev Neurol. 1991;147:467-473.","journal-title":"Rev Neurol"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(92)90045-8"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.4.955"},{"key":"e_1_3_1_9_2","unstructured":"Lach B Preston D Servidei S Embree G DiMauro S Swierenga S. Maternally inherited mitochondrial encephalomyopathy: a vasculopathy. Muscle Nerve. 1986;9(suppl 5)180. Abstract."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260612"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.26.10.1950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:03:45Z","timestamp":1715551425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.26.10.1950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1161\/01.STR.26.10.1950"],"URL":"https:\/\/doi.org\/10.1161\/01.str.26.10.1950","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]},"assertion":[{"value":"1995-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}