{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:45:13Z","timestamp":1774734313328,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,11]]},"abstract":"\n Background<\/jats:italic>\n Animal stroke models demonstrate excitatory amino acid (EAA) release in ischemic tissue, as measured by microdialysis. Currently glutamate antagonist drugs are being developed to protect brain tissue after ischemic events. However, the role of EAAs in human occlusive stroke is not well known. We therefore measured glutamate and aspartate release in a patient after occlusive stroke.\n <\/jats:p>\n \n Case Description<\/jats:italic>\n We describe a case of occlusive stroke in a 50-year-old man. A partial temporal lobectomy was done to remove infarcted tissue and to prevent brain stem compression as well as uncal herniation. A microdialysis probe was placed into the cortex to measure EAAs. Massively increased levels of glutamate and aspartate were detected in the extracellular fluid in this patient (>300 times normal levels 6 days after infarction).\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n These findings indicate that EAAs are tremendously increased in brain tissue after occlusive stroke. The time course of the release of EAAs is much longer than animal studies have suggested previously. Administration of EAA antagonists to patients with ischemic stroke may therefore be beneficial.\n <\/jats:p>","DOI":"10.1161\/01.str.26.11.2187","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2187-2189","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Massive Persistent Release of Excitatory Amino Acids Following Human Occlusive Stroke"],"prefix":"10.1161","volume":"26","author":[{"given":"R.","family":"Bullock","sequence":"first","affiliation":[{"name":"From the Division of Neurosurgery, Medical College of Virginia, Richmond."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zauner","sequence":"additional","affiliation":[{"name":"From the Division of Neurosurgery, Medical College of Virginia, Richmond."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Woodward","sequence":"additional","affiliation":[{"name":"From the Division of Neurosurgery, Medical College of Virginia, Richmond."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.F.","family":"Young","sequence":"additional","affiliation":[{"name":"From the Division of Neurosurgery, Medical College of Virginia, Richmond."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb16583.x"},{"key":"e_1_3_1_2_2","unstructured":"Bullock R Fujisawa H. The role of glutamate antagonists for the treatment of CNS injury. J Neurotrauma. 1992;9(suppl 2):S3443-S3461."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.9.8073477"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb05823.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.5.0794"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.115"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.1.0072"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac50047a019"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90754-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","unstructured":"Hillered L Persson L Carlson H Ungerstedt U Ronne-Engstrom E Nilsson P. Studies on excitatory amino acid receptor-linked brain disorders in rat and man using in vivo microdialysis. Clin Neuropharmacol. 1992;15(suppl 1):695A-696A.","DOI":"10.1097\/00002826-199201001-00359"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","unstructured":"Bullock R Zauner A Tsuji O Woodward JJ Marmarou T Young HF. Patterns of excitatory amino acid release and ionic flux after severe head trauma. In: Tsubokawa T Marmarona A Robertson C Teasdale G eds. Neurochemical Monitoring in the Intensive Care Unit. Tokyo Japan: Springer-Verlag; 1995:64-67.","DOI":"10.1007\/978-4-431-68522-7_7"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.11.7974542"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.26.11.2187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:30:22Z","timestamp":1715553022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.26.11.2187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1161\/01.STR.26.11.2187"],"URL":"https:\/\/doi.org\/10.1161\/01.str.26.11.2187","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"1995-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}