{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:52:02Z","timestamp":1773507122620,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            [\n            <jats:sup>123<\/jats:sup>\n            I]Iomazenil is a single-photon emission computed tomography (SPECT) tracer that selectively binds to central benzodiazepine receptor in the neuron membrane. With this ligand, we studied the central benzodiazepine receptor distribution in the cortex remote from subcortical hematoma in intracerebral hemorrhage patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Four patients with unilateral putaminal hemorrhage and one patient with right thalamic hemorrhage were studied (mean\u00b11 SD age, 50.0\u00b18.8 years). The initial volume of hematoma ranged from 4.3 to 31.0 mL (mean\u00b11 SD, 17.5\u00b112.3 mL). SPECT images obtained 3 hours after intravenous administration of [\n            <jats:sup>123<\/jats:sup>\n            I]iomazenil (167 MBq\/750 ng) were analyzed. In three patients, perfusion was evaluated with [\n            <jats:sup>123<\/jats:sup>\n            I]IMP. On SPECT images, the radioactivity ratio of the ipsilateral to the contralateral cerebral cortex (I\/C ratio) or of the contralateral to the ipsilateral cerebellar hemisphere (C\/I ratio) was measured.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            The I\/C ratio for iomazenil was significantly decreased compared with unity in the temporal lobe (0.84\u00b10.08,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) and the parietal lobe (0.87\u00b10.10,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05), but the C\/I ratio in the cerebellum (1.00\u00b10.03) was not. The C\/I ratio for perfusion in the cerebellar cortex (0.83\u00b10.04,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) was significantly decreased compared with that in normal subjects.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Central benzodiazepine receptor\u2013[\n            <jats:sup>123<\/jats:sup>\n            I]iomazenil binding was decreased in the ipsilateral cerebral cortex remote from the subcortical hematoma. This preliminary result may facilitate further study of the potential damage of the cortical neurons remote from subcortical hematoma.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.12.2267","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"2267-2271","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Central Benzodiazepine Receptor Distribution After Subcortical Hemorrhage Evaluated by Means of [\n            <sup>123<\/sup>\n            I]Iomazenil and SPECT"],"prefix":"10.1161","volume":"26","author":[{"given":"Jun","family":"Hatazawa","sequence":"first","affiliation":[{"name":"From the Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eku","family":"Shimosegawa","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Satoh","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Kanno","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Uemura","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Fisher CM. Clinical syndromes in cerebral hemorrhage. In: Fields WS ed. Pathogenesis and Treatment of Cerebrovascular Disease. Springfield Ill: Charles C Thomas Publishing; 1961:318-338."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/neurosurgery\/23.CN_suppl_1.220"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.4.961"},{"key":"e_1_3_2_4_2","first-page":"1007","volume":"31","year":"1990","unstructured":"Beer HF, Blauenstein PA, Hasler PH, Delaloye B, Riccabona G, Bangerl I, Hunkeler W, Bonetti EP, Pieri L, Richards JG, Schubiger PA. In vitro and in vivo evaluation of Iodine-123 Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors. J Nucl Med. 1990;31:1007-1014.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_5_2","first-page":"228","volume":"35","year":"1994","unstructured":"Abi-Dargham A, Laruelle M, Seibyl J, Ratter Z, Baldwin RM, Zoghbi SS, Zea-Ponce Y, Bremner JD, Hyde TM, Charney DS, Hoffer PB, Innis RB. SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. J Nucl Med. 1994;35:228-238.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_6_2","unstructured":"Benavides J Serrano A Duval D Bourdiol F Toulmond S Scatton B. Autoradiographic detection and quantitation of traumatic brain lesions in the rat brain by using site radioligands. In: Kriegstein J Oberpichler H eds. Pharmacology of Cerebral Ischemia. Stuttgart Germany: Wissenschaftliche Verlagsgesellschaft mbH; 1989:39-45."},{"key":"e_1_3_2_7_2","unstructured":"Hatazawa J Satoh T Shimosegawa E Okudera T Inugami A Ogawa T Fujita H Noguchi K Kanno I Miura S Murakami M Iida H Miura Y Uemura K. Evaluation of cerebral infarction with iodine-123-iomazenil SPECT. J Nucl Med. 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