{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:08:30Z","timestamp":1744888110047},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Progressive stenosis or occlusion of bilateral internal carotid arteries by fibrocellular intimal thickening results in cerebral ischemia in moyamoya disease. In an attempt to elucidate the still-unknown etiologic factors in moyamoya disease, we assessed human leukocyte antigens in patients with this disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We investigated 32 unrelated Japanese patients with moyamoya disease for typing of human leukocyte antigen A, B, C, and DR\/DQ and compared the results with those from 178 unrelated control subjects.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            We found a significant association of human leukocyte antigen B51 with moyamoya disease (corrected\n            <jats:italic>P<\/jats:italic>\n            &lt;.05, \u03c7\n            <jats:sup>2<\/jats:sup>\n            test). Although no significant associations were observed in DR\/DQ typing, the frequency of the B51-DR4 combination was significantly higher in moyamoya patients than in control subjects (\n            <jats:italic>P<\/jats:italic>\n            &lt;.002, Fisher\u2019s exact test).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            These findings suggest that there may be a genetic predisposition for moyamoya disease and that host factors may play a role in the development of intimal thickening in early childhood.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.3.415","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"415-417","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Human Leukocyte Antigen in Patients With Moyamoya Disease"],"prefix":"10.1161","volume":"26","author":[{"given":"Masaru","family":"Aoyagi","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ogami","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Matsushima","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Shikata","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.5.485"},{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Nishimoto A Takeuchi S. Abnormal cerebrovascular network related to the internal carotid arteries. J Neurosurg. 1968;29: 255-260.","DOI":"10.3171\/jns.1968.29.3.0255"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.1.6823678"},{"key":"e_1_3_2_5_2","first-page":"221","volume":"19","year":"1984","unstructured":"Hosoda Y. Pathology of so-called \u201cspontaneous occlusion of the circle of Willis.\u201d Pathol Annu. 1984;19:221-244.","journal-title":"Pathol Annu"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.1.6823686"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.11.1750042"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.32.883"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.3.208"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Tiwari JL Terasaki PI. 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