{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:18:48Z","timestamp":1789460328685,"version":"build-2803163510"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Apolipoprotein E (apoE) \u03b54 allele has been associated with a high risk for coronary heart disease. Increased frequency of the \u03b54 allele has also been reported in patients with late-onset familial and sporadic Alzheimer\u2019s disease (AD). The aim of this study was to investigate the degree of coronary and cerebral atherosclerosis in a neuropathologically verified series of AD patients with different apoE genotypes. In addition, we studied the relationship between the degree of coronary and cerebral atherosclerosis and the extent of \u03b2-amyloid (A\u03b2) accumulation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We studied 38 subjects (32 patients with definite AD and 6 age-matched control subjects) for whom postmortem autopsy delay was less than 8 hours. ApoE genotypes were identified through\n            <jats:italic>Hha<\/jats:italic>\n            I digestion of the polymerase chain reaction\u2013amplified samples. We used A\u03b2 immunohistochemistry to detect diffuse and neuritic plaques as well as cerebrovascular amyloid. The degree of coronary and cerebral atherosclerosis was rated as none, mild, moderate, or severe.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            The apoE genotypes of the AD patients were \u03b54\/4 2, \u03b53\/4 19, \u03b53\/3 9, and \u03b53\/2 2. We found more severe atherosclerosis of the coronary vessels among AD patients with the apoE \u03b54 allele compared with those AD patients without the \u03b54 allele (\u03c7\n            <jats:sup>2<\/jats:sup>\n            =4.1,\n            <jats:italic>df<\/jats:italic>\n            =1,\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). The extent of cerebral atherosclerosis did not differ among AD subgroups with and without the \u03b54 allele. The degree of coronary or cerebral atherosclerosis was not related to the amount of amyloid accumulation in the frontal and temporal cortices or in the hippocampal structures.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            This study confirms the association of apoE \u03b54 allele with coronary atherosclerosis in AD patients.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.5.743","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"743-748","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Relation of Coronary Atherosclerosis and Apolipoprotein E Genotypes in Alzheimer Patients"],"prefix":"10.1161","volume":"26","author":[{"given":"O.","family":"Kosunen","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Talasniemi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lehtovirta","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Heinonen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Helisalmi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mannermaa","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Palja\u0308rvi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ryyna\u0308nen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr","given":"P.J.","family":"Riekkinen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; and the Harjula Hospital (S.T.), Kuopio, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Soininen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (O.K., L.P.) and Neurology (M.L., O.H., P.J.R., H.S.) and the Unit of Clinical Genetics (S.H., A.M, M.R.) of the Department of Gynecology and Obstetrics, Kuopio University Hospital, University of Kuopio; 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