{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:24:55Z","timestamp":1758479095855},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            We investigated the efficacy and feasibility of determining infarction mechanisms and underlying embolic or hemodynamic pathologies from topographical patterns of ischemic damage seen on computed tomography or magnetic resonance imaging.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Infarction patterns from 22 patients with ipsilateral severe, hemodynamically relevant carotid stenosis (n=6) or occlusions (n=16) were superimposed, using two matching algorithms, onto maps showing the variability of the cerebral vascular territories as determined from recent cadaver studies. These images were used to classify the infarctions as border-zone or territorial for the two conditions of minimal and maximal middle cerebral artery distribution.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Classification of infarction patterns resulting from carotid stenosis was independent of the territorial extension map chosen: 83% were classified as territorial. Classification of patterns due to carotid occlusion, however, varied highly; 81% of infarctions were considered territorial when the maximal middle cerebral artery distribution map was used, whereas only 19% were when the minimal territorial extension map was used.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            The current concept that stroke mechanisms can be inferred from the interpretation of stroke patterns seen on computed tomography scans or magnetic resonance imaging is significantly confounded by the demonstrated variability in intracranial vascular distributions. Stroke pattern interpretation appears to be highly dependent on the in vivo vascular tree of the individual, which is unknown to the examiner. This calls into question the reliability of classifying infarction patterns as border-zone or territorial. Determination of true underlying stroke mechanisms requires a comprehensive approach and cannot be based solely on stroke pattern interpretation.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.6.942","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"942-945","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Variability of Vascular Territory in Stroke"],"prefix":"10.1161","volume":"26","author":[{"given":"Erhard W.","family":"Lang","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Daffertshofer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Daffertshofer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen B.","family":"Wirth","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall M.","family":"Chesnut","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hennerici","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Universita\u0308t Heidelberg, Klinikum Mannheim (E.W.L., M.D., M.H.); the Institute of Theoretical Physics and Synergetics, Department of Physics, Universita\u0308t Stuttgart (A.D.); the Department of Anatomy III and Cell Biology, Universita\u0308t Heidelberg, Heidelberg (S.B.W.), Germany; and the Department of Neurological Surgery, School of Medicine, University of California at San Francisco (R.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.6.6362094"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200312"},{"key":"e_1_3_3_3_2","first-page":"462","volume":"61","year":"1990","unstructured":"Ringelstein EB, Weiller C. 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Radiologe. 1991;31:481-488.","journal-title":"Radiologe"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.3.373"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710003095X"},{"key":"e_1_3_3_15_2","first-page":"99","volume":"1","year":"1982","unstructured":"Torvik A, Skullerud K. Watershed infarcts in the brain caused by microemboli. Clin Neuropathol. 1982;1:99-105.","journal-title":"Clin Neuropathol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.15.2.6701929"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530270131030"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.26.6.942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:32:41Z","timestamp":1715553161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.26.6.942"}},"subtitle":["Pitfalls and Failure of Stroke Pattern Interpretation"],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1161\/01.STR.26.6.942"],"URL":"https:\/\/doi.org\/10.1161\/01.str.26.6.942","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]},"assertion":[{"value":"1994-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}