{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:04:56Z","timestamp":1776276296285,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Percutaneous transluminal angioplasty (PCTA) is increasingly used to treat extracerebral arterial stenosis. The present study evaluates the safety and efficacy of PCTA treatment of symptomatic intracranial atherosclerotic stenosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            A series of 22 vessels in 17 patients were treated with PCTA. All patients had recurrent neurological symptoms referable to the stenotic vessel despite optimal medical therapy. Critical (&gt;70%) arterial stenosis was confirmed by angiogram, and angioplasty was performed with a 3.0- to 3.5-mm Stealth balloon.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            The average preangioplasty stenosis (North American Symptomatic Carotid Endarterectomy Trial criteria) was 72\u00b18% (mean\u00b1SD), with a significant improvement seen after angioplasty; the best angiographic stenosis (after healing of intimal injury, if any) was 43\u00b124% (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). Overall PCTA was successful in 82% of the vessels. There were two strokes during angioplasty for a 30-day morbidity rate of 9.1% per treated vessel and 11.7% per case. The other 15 patients were clinically evaluated at 3 and 6 months; all cases were without further events. Restenosis was evaluated in 8 patients (12 vessels) with an angiogram at 6 months showing further improvement compared with the initial post-PCTA stenosis (51\u00b110% versus 37\u00b121% [\n            <jats:italic>P<\/jats:italic>\n            =.05]).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            PCTA may be a beneficial therapy in selected cases of symptomatic intracranial atherosclerotic stenosis. Further study using a randomized trial is needed.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.7.1200","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1200-1204","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":134,"title":["Safety and Efficacy of Percutaneous Transluminal Angioplasty for Intracranial Atherosclerotic Stenosis"],"prefix":"10.1161","volume":"26","author":[{"given":"Wayne M.","family":"Clark","sequence":"first","affiliation":[{"name":"From the Oregon Stroke Center, Departments of Neurology (W.M.C., M.L.W., B.M.C.), Neurosurgery, Radiology, and the Dotter Interventional Institute (W.M.C., S.L.B., G.N.), Oregon Health Sciences University, Portland; and the Neurology (B.M.C.) and Neurosurgery (O.R.O\u2019B.) Services, Portland Veterans Administration Medical Center, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley L.","family":"Barnwell","sequence":"additional","affiliation":[{"name":"From the Oregon Stroke Center, Departments of Neurology (W.M.C., M.L.W., B.M.C.), Neurosurgery, Radiology, and the Dotter Interventional Institute (W.M.C., S.L.B., G.N.), Oregon Health Sciences University, Portland; and the Neurology (B.M.C.) and Neurosurgery (O.R.O\u2019B.) Services, Portland Veterans Administration Medical Center, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Nesbit","sequence":"additional","affiliation":[{"name":"From the Oregon Stroke Center, Departments of Neurology (W.M.C., M.L.W., B.M.C.), Neurosurgery, Radiology, and the Dotter Interventional Institute (W.M.C., S.L.B., G.N.), Oregon Health Sciences University, Portland; and the Neurology (B.M.C.) and Neurosurgery (O.R.O\u2019B.) Services, Portland Veterans Administration Medical Center, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oisin R.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"From the Oregon Stroke Center, Departments of Neurology (W.M.C., M.L.W., B.M.C.), Neurosurgery, Radiology, and the Dotter Interventional Institute (W.M.C., S.L.B., G.N.), Oregon Health Sciences University, Portland; and the Neurology (B.M.C.) and Neurosurgery (O.R.O\u2019B.) Services, Portland Veterans Administration Medical Center, Oregon."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Wynn","sequence":"additional","affiliation":[{"name":"From the Oregon Stroke Center, Departments of Neurology (W.M.C., M.L.W., B.M.C.), Neurosurgery, Radiology, and the Dotter Interventional Institute (W.M.C., S.L.B., G.N.), Oregon Health Sciences University, Portland; and the Neurology (B.M.C.) and Neurosurgery (O.R.O\u2019B.) 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