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The objectives of this study were to determine whether the term Binswanger\u2019s disease merits acceptance as a distinct clinicopathologic entity, to deduce the clinical significance of these white matter abnormalities from the analysis of appropriate publications, and to evaluate studies that correlate in vivo changes in the cerebral white matter with pathological features.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Summary of Review<\/jats:italic>\n            We evaluated Binswanger\u2019s original case description and, after conducting a Medline search, reviewed more than 160 publications, mostly in the English language, on the subject of white matter abnormalities detectable by currently used neuroimaging methods (ie, leukoaraiosis).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Binswanger\u2019s original description appears to be insufficient for the purpose of defining a new nosological entity. After evaluating the vaguely outlined pathological correlates described in a few of these subcortical cerebral leukoencephalopathies, we conclude that the clinical significance of leukoaraiosis remains incompletely defined. However, its frequency increases with age independent of other risk factors, and in nondemented subjects leukoaraiosis is associated with deficits in selected cognitive functions. Moreover, leukoaraiosis correlates with an increased risk for the subsequent development of strokes. We make specific suggestions for future studies that may help to clarify this topic.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.7.1293","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1293-1301","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":371,"title":["The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger\u2019s Report"],"prefix":"10.1161","volume":"26","author":[{"given":"Leonardo","family":"Pantoni","sequence":"first","affiliation":[{"name":"From the Department of Pathology (Neuropathology), Henry Ford Hospital, Detroit, Mich (L.P., J.H.G.); the Department of Pathology (Neuropathology), Case Western Reserve University, Cleveland, Ohio (J.H.G.); and the Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Department of Pathology (Neuropathology), Henry Ford Hospital, Detroit, Mich (L.P., J.H.G.); the Department of Pathology (Neuropathology), Case Western Reserve University, Cleveland, Ohio (J.H.G.); and the Department of Neurological and Psychiatric Sciences, University of Florence (Italy) (L.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"1102","volume":"31","year":"1894","unstructured":"Binswanger O. 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