{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:46:21Z","timestamp":1760100381088},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Transcranial Doppler sonography (TCD) has been used to detect microembolic signals in a variety of clinical situations. We studied the prevalence of TCD-detected microemboli in 38 acute stroke patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Consecutive patients with acute anterior circulation stroke were stratified into high-risk (group 1), medium-risk (group 2), and low-risk (group 3) groups based on their risk factors for cerebral embolism.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Microemboli were detected in 11% of patients. They were present in 17% of group 1, 10% of group 2, and 0% of group 3 patients. Emboli were present in patients with mechanical prosthetic valves, carotid stenosis (&gt;70%), and mitral valve strands with a patent foramen ovale. Patients with microemboli more frequently had a history of cerebral ischemia compared with patients without microemboli (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). They also more frequently had recent (&lt;3 months) symptoms compared with patients without microemboli (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). In patients with a cardiac source of embolization, the number of microemboli detected was directly proportional to the acuity of previous symptoms.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            These data suggest that TCD-detected microemboli are associated with an increased prevalence of prior cerebrovascular ischemia. The presence of TCD-detected microemboli could be a risk factor for cerebrovascular ischemia.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.9.1588","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1588-1592","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Transcranial Doppler\u2013Detected Microemboli in Patients With Acute Stroke"],"prefix":"10.1161","volume":"26","author":[{"given":"David C.","family":"Tong","sequence":"first","affiliation":[{"name":"From the Stanford Stroke Center, Department of Neurology and Neurologic Sciences, Stanford University Medical Center, Palo Alto, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center, Department of Neurology and Neurologic Sciences, Stanford University Medical Center, Palo Alto, Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.3.2408197"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/153857449002400107"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.3.8128512"},{"key":"e_1_3_1_4_2","first-page":"37","volume":"2","year":"1993","unstructured":"Rams JJ, Davis AD, Lolley MD, Berger PM, Spencer MP. Detection of microemboli in patients with artificial heart valves using transcranial Doppler: preliminary observations. J Heart Valve Dis. 1993;2:37-41.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Deklunder GM Dauzat MM Aldis A Burte FM Stewart SF Houdas YJ. Microbubbles cerebral emboli detected by transcranial Doppler sonography in patients with prosthetic heart valves. Circulation. 1993;88(pt 2):I-223. Abstract.","DOI":"10.7863\/jum.1994.13.2.129"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.11.1440714"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.5.1005"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.8.7913775"},{"key":"e_1_3_1_9_2","first-page":"283","volume":"9","year":"1990","unstructured":"Tegeler CH, Hitchings LP, Eicke M, Leighton J, Fredericks RK, Downes TR, Stump DA, Burke GL. 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New York NY: Raven Press Publishers; 1993:215-230."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","unstructured":"Heath D Best P Davis B. Papilliferous tumors of the heart valves. Br Heart J. 1961:23;20-24.","DOI":"10.1136\/hrt.23.1.20"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90276-2"},{"key":"e_1_3_1_22_2","first-page":"218A","volume":"21","year":"1993","unstructured":"Orsinelli DA, Pearson AC. Detection of prosthetic valve strands by transesophageal echocardiography: clinical significance in patients with suspected cardiac source of embolus. J Am Coll Cardiol. 1993;21:218A. Abstract.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805053181802"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92944-3"},{"key":"e_1_3_1_25_2","first-page":"461","volume":"117","year":"1992","unstructured":"DiTullio M, Sacco R, Gopal A, Mohr J, Homma S. 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