{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:18:25Z","timestamp":1759033105563},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Single, oval lesions greater than 5 mm in diameter lying inferior to the lateral putamen (infraputaminal lacunes [IPLs]) seen on CT or MR images are commonly reported as lacunar infarcts. To determine the clinical relevance and underlying pathology of IPLs, we evaluated the imaging appearances, clinical features, vascular risk factors, and histopathology in patients with IPLs.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Consecutive MR scans were reviewed for the presence of IPLs. Serial patients seen in routine clinical practice with IPLs were also included. Vascular risk factors were obtained from a prescan questionnaire. Histology and microangiography were performed on postmortem material. A MEDLINE search for putaminal infarcts was performed to look for imaging lesions typical of IPLs.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Three of 100 serial MR scans had IPLs (3%). Nine other patients with in vivo (7) or postmortem (2) MR scans had IPLs. No neurological symptoms could be related to the IPLs. There were no differences in age, hypertension, diabetes, or presence of cortical enlarged perivascular spaces (EPVSs) between patients with and without IPLs. Unlike infarcts, IPLs were isointense with the cerebrospinal fluid on proton density MR sequences. Histological correlation of three MR scans showed IPLs to be a single large EPVS, situated lateral to the anterior commissure. IPLs were located at a point where multiple lenticulostriates turn sharply dorsally. An IPL was the probable cause of the apparent infarct in six publications from peer-reviewed literature that linked different clinical signs to putaminal infarct.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            IPLs are EPVSs that can be differentiated from infarcts on proton density MR images.\n          <\/jats:p>","DOI":"10.1161\/01.str.26.9.1598","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1598-1602","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Infraputaminal \u2018Lacunes\u2019"],"prefix":"10.1161","volume":"26","author":[{"given":"Patrick M.","family":"Pullicino","sequence":"first","affiliation":[{"name":"From the Department of Neurology (P.M.P., A.V.A.) and Division of Neuropathology, Department of Pathology (L.L.M., P.T.O.), Buffalo General Hospital, State University of New York, Buffalo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia L.","family":"Miller","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (P.M.P., A.V.A.) and Division of Neuropathology, Department of Pathology (L.L.M., P.T.O.), Buffalo General Hospital, State University of New York, Buffalo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei V.","family":"Alexandrov","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (P.M.P., A.V.A.) and Division of Neuropathology, Department of Pathology (L.L.M., P.T.O.), Buffalo General Hospital, State University of New York, Buffalo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Ostrow","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (P.M.P., A.V.A.) and Division of Neuropathology, Department of Pathology (L.L.M., P.T.O.), Buffalo General Hospital, State University of New York, Buffalo."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"281","volume":"21","year":"1901","unstructured":"Marie P. Des foyers lacunaires de d\u00e9sint\u00e9gration et de diff\u00e9rents autres \u00e9tats cavitaires du cerveau. Rev Med. 1901;21:281-298.","journal-title":"Rev Med"},{"key":"e_1_3_1_2_2","first-page":"138","volume":"2","year":"1983","unstructured":"Poirier J. Giant cerebral lacuna due to dilatation of the perivascular space: a case report. Clin Neuropathol. 1983;2:138-140.","journal-title":"Clin Neuropathol"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.1.3420242"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.151.3.551"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.6.874"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.139.2.6971454"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.6.3810737"},{"key":"e_1_3_1_8_2","first-page":"104","volume":"50","year":"1987","unstructured":"Mas J-L, Launay M, Derouesn\u00e9 C. Hemiballism and CT-documented lacunar infarct in the lenticular nucleus. J Neurol Neurosurg Psychiatry. 1987;50:104-118.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080219"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.11.7974556"},{"key":"e_1_3_1_11_2","first-page":"891","volume":"6","year":"1995","unstructured":"Tatter SB, Buonanno FS, Ogilvy CS. Acute lacunar stroke in asso-ciation with angiogram-negative subarachnoid hemorrhage. Stroke. 1995;6:891-895.","journal-title":"Stroke"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.6.8202968"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.761"},{"key":"e_1_3_1_14_2","first-page":"929","volume":"10","year":"1989","unstructured":"Heier LA, Bauer CJ, Schwartz L, Zimmerman RD, Morgello S, Deck MDF. Large Virchow-Robin spaces: MR-clinical correlation. AJNR Am J Neuroradiol. 1989;10:929-936.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_15_2","first-page":"349","volume":"139","year":"1983","unstructured":"Poirier J, Barbizet J, Gaston A, Meyrignac C. D\u00e9mence thalamique: lacunes expansives du territoire thalamo-m\u00e9senc\u00e9phalique param\u00e9dian: hydroc\u00e9phalie par st\u00e9nose de l\u2019aqueduc de Sylvius. Rev Neurol. 1983;139:349-358.","journal-title":"Rev Neurol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500380035003"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090323"},{"key":"e_1_3_1_18_2","first-page":"19","volume":"1","year":"1965","unstructured":"Hughes W. Origin of lacunes. Lancet. 1965;1:19-21.","journal-title":"Lancet"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.26.9.1598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:02:34Z","timestamp":1715551354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.26.9.1598"}},"subtitle":["Clinical and Pathological Correlations"],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1161\/01.STR.26.9.1598"],"URL":"https:\/\/doi.org\/10.1161\/01.str.26.9.1598","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"1995-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}