{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:26:45Z","timestamp":1772915205023,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Resistance to activated protein C is a common inherited risk factor for venous thrombosis, which is due to a mutation in coagulation factor V (factor V Leiden mutation). It is present in approximately 20% of unselected consecutive patients with deep vein thrombosis. The rate of resistance to activated protein C in patients with cerebral venous thrombosis (CVT) is unknown.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We investigated the association of factor V mutation with CVT using a case-control study. Nineteen unselected patients with CVT and 57 healthy control subjects were tested for the point mutation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            The mutation was found in a heterozygous form in 4 of the 19 patients with CVT (21%) and in only 1 of the 57 control subjects (2%) (\n            <jats:italic>P<\/jats:italic>\n            =.02, Fisher's exact test). The prevalence of the coagulation defect found in our patients with CVT was consistent with that observed in previous studies in patients with deep vein thrombosis. In 3 of the 4 patients positive for the mutation, CVT developed in the presence of an acquired prothrombotic state, including oral contraceptive use in 2 patients and puerperium in the third.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Factor V Leiden mutation is a risk factor for CVT and may be the most common inherited coagulation defect associated with this condition.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.10.1721","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1721-1723","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":104,"title":["Factor V Leiden Mutation in Cerebral Venous Thrombosis"],"prefix":"10.1161","volume":"27","author":[{"given":"Mathieu","family":"Zuber","sequence":"first","affiliation":[{"name":"the Service de Neurologie, Centre R. Garcin, Ho\u0302pital Sainte-Anne (M.Z., J.-L.M.), and Laboratoire d'He\u0301mostase, Ho\u0302pital Cochin (P.T., L.M.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Toulon","sequence":"additional","affiliation":[{"name":"the Service de Neurologie, Centre R. Garcin, Ho\u0302pital Sainte-Anne (M.Z., J.-L.M.), and Laboratoire d'He\u0301mostase, Ho\u0302pital Cochin (P.T., L.M.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Marnet","sequence":"additional","affiliation":[{"name":"the Service de Neurologie, Centre R. Garcin, Ho\u0302pital Sainte-Anne (M.Z., J.-L.M.), and Laboratoire d'He\u0301mostase, Ho\u0302pital Cochin (P.T., L.M.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Mas","sequence":"additional","affiliation":[{"name":"the Service de Neurologie, Centre R. Garcin, Ho\u0302pital Sainte-Anne (M.Z., J.-L.M.), and Laboratoire d'He\u0301mostase, Ho\u0302pital Cochin (P.T., L.M.), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)80081-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300801"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321403"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.6.1504.bloodjournal8561504"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92940-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.5.885"},{"key":"e_1_3_2_9_2","first-page":"1266","volume":"274","year":"1995","unstructured":"Bachmeyer C, Toulon P, Zuber M, Dhote R, Mas JL, Christoforov B. Ischemic stroke and activated protein C resistance. JAMA. 1995;274:1266. Abstract.","journal-title":"JAMA"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653820"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30235-4"},{"key":"e_1_3_2_12_2","unstructured":"Yasargil MG Damur M. Thrombosis of the cerebral veins and dural sinuses. In: Newton TH Potts DG eds. Radiology of the Skull and Brain: Angiography. Book 4. St Louis Mo: CV Mosby Co; 1974:2375-2400."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.9.2396274"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.1.1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649670"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199505000-00008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650284"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.433"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92888-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90286-0"},{"key":"e_1_3_2_22_2","first-page":"1162","volume":"344","year":"1994","unstructured":"Baker R, Thom J, van Bockxmeer F. Diagnosis of activated protein C resistance (factor V Leiden). Lancet. 1994;344:1162. Abstract.","journal-title":"Lancet"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.27.10.1721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:07:24Z","timestamp":1715551644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.27.10.1721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1161\/01.STR.27.10.1721"],"URL":"https:\/\/doi.org\/10.1161\/01.str.27.10.1721","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]},"assertion":[{"value":"1996-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}