{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:48:46Z","timestamp":1791902926946,"version":"4.3.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Cerebral venous thrombosis (CVT) is an infrequent condition with a large variety of causes. However, in 20% to 35% of cases, no cause is found. We studied coagulation parameters, including activated protein C resistance associated with factor V gene mutation (factor V Leiden) and anticardiolipin antibodies, in a large series of patients with CVT with or without identified cause or risk factor.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Forty patients (30 women and 10 men) aged 19 to 71 years (mean age, 36.2 years) with CVT diagnosed by angiography and\/or MRI were studied 1 to 18 years after thrombosis. No known cause was found in 10 idiopathic cases. Coagulation studies included the following tests: fibrinogen, antithrombin, protein C, protein S, plasminogen, anticardiolipin antibodies, activated protein C resistance, and factor V Leiden.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Six cases of thrombophilia (15%) were found: 1 protein C deficiency, 1 protein S deficiency, and 4 activated protein C resistance with heterozygous factor V Leiden mutation (10%). Only 1 case (protein S deficiency) was found in the group of 10 patients with idiopathic CVT. In the other 5, there was another cause or risk factor. Three patients (8%) had increased anticardiolipin antibodies: 1 with systemic lupus and 2 with primary antiphospholipid syndrome; 2 of these 3 patients also had factor V Leiden mutation.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Although present in a number of CVT cases, acquired (anticardiolipin) or congenital varieties of thrombophilia (factor V Leiden being the most frequent) are almost invariably associated with other predisposing factors. This suggests that (1) these abnormalities should be looked for in patients with CVT, whether a cause is found or not, and (2) their presence should not deter the search for other potential causes. The detection of such abnormalities has major practical consequences on the long-term management of patients to prevent further thrombotic episodes.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.10.1724","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1724-1730","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":185,"title":["Coagulation Studies, Factor V Leiden, and Anticardiolipin Antibodies in 40 Cases of Cerebral Venous Thrombosis"],"prefix":"10.1161","volume":"27","author":[{"given":"Marie-Anne","family":"Deschiens","sequence":"first","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Conard","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie He\u0301le\u0300ne","family":"Horellou","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ameri","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Preter","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Chedru","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyer Michel","family":"Samama","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[{"name":"the Service de Neurologie Ho\u0302pital Saint-Antoine (M.-A.D., M.P., M.G.B.) and the Service d'He\u0301matologie Biologique, Ho\u0302tel-Dieu (J.C., M.H.H., M.S.), Paris; and the Service de Neurologie, Ho\u0302pital de Meaux, Meaux (A.A., F.C.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30235-4"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)80081-9"},{"key":"e_1_3_1_5_2","first-page":"209","volume":"24","year":"1995","unstructured":"Trossa\u00ebrt M, Conard J, Horellou MH, Samaha M, Elalamy I, Samama MM. 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