{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:25:24Z","timestamp":1774963524124,"version":"3.50.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Echolucent carotid atherosclerotic plaques are associated with an increased risk of neurological symptoms. Elevated plasma triglycerides is a risk factor for cerebral and coronary infarction. This study examined these individual pathogenetic risk factors to determine whether they were related.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We included 85 symptomatic patients with at least 40% carotid artery stenosis. Plaque morphology of the relevant artery was evaluated by high-resolution B-mode ultrasonography as echolucent, echo-rich, or intermediate. Fasting and postprandial lipids and lipoproteins were measured before and at hourly intervals for 4 hours after a fatty meal (1 g cream fat per kilogram body weight).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            When we compared patients with echolucent plaques to patients with echo-rich or intermediate plaques, the former had higher fasting and postprandial plasma triglycerides (\n            <jats:italic>P<\/jats:italic>\n            \u2264.006), higher chylomicron remnants\/VLDL cholesterol (\n            <jats:italic>P<\/jats:italic>\n            =.02) and triglycerides (\n            <jats:italic>P<\/jats:italic>\n            \u2264.004), a larger area under the plasma triglyceride curve 0 to 4 hours after a fatty meal, with (AUC\n            <jats:sub>TG\u2212TG 0h<\/jats:sub>\n            ) or without (AUC\n            <jats:sub>TG<\/jats:sub>\n            ) subtraction of fasting levels (\n            <jats:italic>P<\/jats:italic>\n            =.007 and\n            <jats:italic>P<\/jats:italic>\n            =.003), a larger body mass index (\n            <jats:italic>P<\/jats:italic>\n            =.03), and were younger (\n            <jats:italic>P<\/jats:italic>\n            =.01). Multiple logistic regression analysis found that when age and body mass index were taken into account, fasting plasma and VLDL triglycerides, postprandial chylomicron remnants\/VLDL triglycerides, AUC\n            <jats:sub>TG\u2212TG 0h<\/jats:sub>\n            and AUC\n            <jats:sub>TG<\/jats:sub>\n            with odds ratios of 4.1, 3.8, 3.0, 2.7, and 4.3, respectively, were independent predictors of an echolucent plaque.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Echolucent carotid artery plaques are associated with elevated levels of triglyceride-rich lipoproteins in the fasting or postprandial state.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.12.2166","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"2166-2172","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Echolucent Carotid Artery Plaques Are Associated With Elevated Levels of Fasting and Postprandial Triglyceride-Rich Lipoproteins"],"prefix":"10.1161","volume":"27","author":[{"given":"Marie-Louise Moes","family":"Gr\u00f8nholdt","sequence":"first","affiliation":[{"name":"the Department of Vascular Surgery, Rigshospitalet, and the Department of Clinical Biochemistry, Herlev Hospital (B.G.N.), University of Copenhagen (Denmark)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"the Department of Vascular Surgery, Rigshospitalet, and the Department of Clinical Biochemistry, Herlev Hospital (B.G.N.), University of Copenhagen (Denmark)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina G.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"the Department of Vascular Surgery, Rigshospitalet, and the Department of Clinical Biochemistry, Herlev Hospital (B.G.N.), University of Copenhagen (Denmark)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Sillesen","sequence":"additional","affiliation":[{"name":"the Department of Vascular Surgery, Rigshospitalet, and the Department of Clinical Biochemistry, Herlev Hospital (B.G.N.), University of Copenhagen (Denmark)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060388"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.83.6.2040066"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390230069027"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231901"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.2.438"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.20"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.4.7734010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80580-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.7.1758"},{"key":"e_1_3_2_10_2","first-page":"1383","volume":"344","year":"1994","unstructured":"Scandianvian Simvastatin Survival Study Group. 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