{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:04:37Z","timestamp":1715558677896},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Low pulsatility signals (LPS) on transcranial Doppler ultrasonography are detected (1) with arteriovenous malformations, (2) distal to hemodynamically significant stenosis, and (3) in venous structures. We describe focal LPS in the territory of the internal carotid artery siphon that do not represent any of the above conditions.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We performed retrospective and prospective reviews of transcranial Doppler studies on 3225 patients over 5 years. Clinical and radiological data of all patients with focal LPS were extracted. LPS was defined as a focal signal identified through the orbital windows with a low pulsatility index (&lt;0.6).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Sixteen LPS (mean flow velocity [mean\u00b1SD], 62\u00b111 cm\/s; pulsatility index [mean\u00b1SD], 0.41\u00b10.08; depth range, 46 to 72 mm) from 15 patients (mean\u00b1SD age, 45\u00b115 years; 4 men, 11 women) were identified. LPS flow direction was away from the probe in 13 cases and toward it in 3. Presenting symptoms included headache, focal neurological deficits, dizziness, and pulsatile tinnitus. All patients had cranial MRI (MRI and MR angiography in 11). Three patients underwent conventional cerebral angiography. Arteriovenous malformations or significant arterial stenoses were not detected on any study.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            A focal signal from the internal carotid artery siphon region with low pulsatility index and normal mean flow velocity, identified in the absence of other transcranial Doppler abnormalities, is not related to an arteriovenous malformation or proximal arterial stenosis. LPS, as defined, are not of venous origin since mean flow velocity was in the arterial range. LPS are likely related to prominent venous flow in the cavernous sinus secondary to unusually strong pulsation of the intracavernous internal carotid artery.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.2.300","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"300-302","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Low Pulsatility Signals Through the Orbits"],"prefix":"10.1161","volume":"27","author":[{"given":"Constantinos","family":"Gymnopoulos","sequence":"first","affiliation":[{"name":"From the Cerebrovascular Laboratory, Center for Stroke Research, Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabih M.","family":"Ramadan","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Laboratory, Center for Stroke Research, Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Mich."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.4.680"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.4.696"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.9.2204147"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.6.1123"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.5.3284020"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.3.0335"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.54"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90251-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3532437"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.10.7916499"},{"key":"e_1_3_1_12_2","unstructured":"Lindergaard K-F. Indices of pulsatility. In: Newell DW Aaslid R eds. Transcranial Doppler. 2nd ed. New York NY: Raven Press; 1992:67-82."},{"key":"e_1_3_1_13_2","unstructured":"DeWitt LD Rosengart A Teal PA. Transcranial Doppler ultrasonography: normal values. In: Babikian VL Weschler LR eds. Transcranial Doppler Ultrasonography. St Louis Mo: CV Mosby Co; 1993:29-38."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.6.0890"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.5.626"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.9.1926257"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.7.1196"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198905000-00015"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(92)90167-L"},{"key":"e_1_3_1_20_2","unstructured":"Parkinson D West M. Lesions of the cavernous plexus region. In: Yumans JR ed. Neurological Surgery. 3rd ed. Philadelphia Pa: WB Saunders Co; 1990:3351-3370."},{"key":"e_1_3_1_21_2","unstructured":"Doyon DL Aron-Rosa DS Ram\u00e9e A. Orbital veins and cavernous sinus. In: Newton TH Gordon Potts D eds. Radiology of the Skull and Brain. St Louis Mo: CV Mosby Co; 1974:2220-2256."}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.27.2.300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:22:59Z","timestamp":1715552579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.27.2.300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1161\/01.STR.27.2.300"],"URL":"https:\/\/doi.org\/10.1161\/01.str.27.2.300","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]},"assertion":[{"value":"1995-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}