{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:44:22Z","timestamp":1759178662683},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            By assessment of metabolically induced cerebral blood flow velocity changes, transcranial Doppler sonography offers the opportunity to evaluate vasoneuronal coupling in different states of brain activation and in critically ill patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            With simultaneous transcranial Doppler monitoring of the posterior cerebral artery (PCA) and the middle cerebral artery (MCA), 27 control subjects, 11 patients under general anesthesia, 5 patients in the vegetative state, and 12 patients with aneurysmal subarachnoid hemorrhage were stimulated with a 10-Hz flashlight for 30 seconds. Ten cycles of stimulation were averaged, and a specific flow response (SFR) was computed as the normalized ratio of PCA\/MCA mean flow velocity.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Maximal SFR was 14.2% in control subjects. Eye closure significantly reduced maximal SFR (11.6% versus 15.4%,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01). In subarachnoid hemorrhage, SFR was markedly decreased in the early phase (4.8%,\n            <jats:italic>P<\/jats:italic>\n            &lt;.01) but became normal later on. Four of 5 patients with abolished SFR suffered delayed ischemia due to vasospasm. Of 7 patients with preserved SFR, 5 had vasospasm but none had delayed ischemia. No SFR was observed in patients under general anesthesia or in the vegetative state.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Although reflecting fast and local neuronal activity patterns, metabolically induced blood flow response is highly dependent on stimulus-directed attention. In subarachnoid hemorrhage, decreased metabolic flow response suggests severe depression of vasoneuronal coupling, and abolished SFR might indicate increased vulnerability to vasospasm and a higher risk for delayed ischemia.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.3.446","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"446-449","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Visually Evoked Cerebral Blood Flow Velocity Changes in Different States of Brain Dysfunction"],"prefix":"10.1161","volume":"27","author":[{"given":"Veit U.","family":"Becker","sequence":"first","affiliation":[{"name":"From the Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans C.","family":"Hansen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Brewitt","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Thie","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6970412"},{"key":"e_1_3_1_2_2","first-page":"1109","volume":"5","year":"1984","unstructured":"Fox PT, Raichle ME. Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography. J Neurophysiol. 1984;5:1109-1120.","journal-title":"J Neurophysiol"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90004-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.4.3299883"},{"key":"e_1_3_1_5_2","unstructured":"Wittich I Klingelh\u00f6fer J Matzander G Sander D Conrad B. Dynamics of visually evoked perfusion changes in the posterior cerebral artery territory. Cerebrovasc Dis. 1994;4(suppl 3):3. Abstract."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00275003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.12.2264083"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon19922265"},{"key":"e_1_3_1_9_2","unstructured":"Niehaus LB. Visuell evozierte Perfusions\u00e4nderungen bei Posteriorinfarkten. In: Jerusalem F Ries F eds. Verhandlungen der Deutschen Gesellschaft f\u00fcr Neurologie. Berlin Germany: Springer; 1994:935-936."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00867591"},{"key":"e_1_3_1_11_2","unstructured":"Fujioka KA Douville CM. Anatomy and freehand techniques. In: Newell DW Aaslid R eds. Transcranial Doppler. New York NY: Raven Press Publishers; 1992:9-31."},{"key":"e_1_3_1_12_2","unstructured":"Sorteberg W. Cerebral artery blood velocity and cerebral blood flow. In: Newell DW Aaslid R eds. Transcranial Doppler. New York NY: Raven Press Publishers; 1992:57-66."},{"key":"e_1_3_1_13_2","first-page":"243","volume":"3","year":"1981","unstructured":"Berne RM, Winn HR, Rubio R. The local regulation of cerebral blood flow. Prog Cardiovasc Dis. 1981;3:243-260.","journal-title":"Prog Cardiovasc Dis"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.60.5.0883"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.3.413"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","unstructured":"Kuschinsky W. Is the EEG correlated with the brain metabolism and cerebral blood flow? In: Zschocke S Speckmann EJ eds. Basic Mechanism of the EEG. Boston Mass: Birkh\u00e4user; 1993:109-121.","DOI":"10.1007\/978-1-4612-0341-4_8"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.12.4.6976021"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.9.1926257"},{"key":"e_1_3_1_19_2","unstructured":"Sakabe T Nakakimura K. Effects of anesthetic agents and other drugs on cerebral blood flow metabolism and intracranial pressure. In: Cottrell JE Smith DS eds. Anesthesia and Neurosurgery. St Louis Mo: CV Mosby; 1994:149-174."},{"key":"e_1_3_1_20_2","first-page":"109","volume":"80","year":"1990","unstructured":"Jakobsen M, Overgaard J, Marcussen E, Enevoldsen EM. Relation between angiographic cerebral vasospasm and regional CBF in patients with SAH. Acta Neurol Scand. 1990;80:109-115.","journal-title":"Acta Neurol Scand"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.143"},{"key":"e_1_3_1_22_2","first-page":"1","volume":"1","year":"1975","unstructured":"Fein JM. Cerebral energy metabolism after subarachnoid hemorrhage. Stroke. 1975;1:1-8.","journal-title":"Stroke"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.27.3.446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:01:33Z","timestamp":1715551293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.27.3.446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1161\/01.STR.27.3.446"],"URL":"https:\/\/doi.org\/10.1161\/01.str.27.3.446","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"1995-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}