{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:04:11Z","timestamp":1780067051746,"version":"3.54.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            Thrombus within the carotid artery usually occurs in vessels with severe atherosclerotic disease and may embolize to cause transient ischemic attacks and cerebral infarctions. The risk factors for carotid artery thrombus formation in the absence of atherosclerosis are not well characterized. A case series is presented that suggests an association of carotid artery thrombus with severe iron-deficiency anemia and thrombocytosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Descriptions<\/jats:italic>\n            We describe three women with severe iron-deficiency anemia and thrombocytosis secondary to menorrhagia who developed carotid artery thrombi. Thrombi were detected radiographically. The patients were treated with anticoagulation and antiplatelet therapy. In two patients, follow-up neuroimaging 10 to 14 days later demonstrated resolution of the thrombus and no identifiable vascular disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Severe iron-deficiency anemia with thrombocytosis may be a risk factor for carotid artery thrombus formation. Medical management with anticoagulation and antiplatelet therapy is a reasonable approach for these patients while the thrombus resolves.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.5.1002","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1002-1005","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Carotid Artery Thrombus Associated With Severe Iron-Deficiency Anemia and Thrombocytosis"],"prefix":"10.1161","volume":"27","author":[{"given":"Paul T.","family":"Akins","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Washington University School of Medicine, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Glenn","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Washington University School of Medicine, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patti M.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Washington University School of Medicine, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Washington University School of Medicine, St Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.6.3376159"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.9.3.644626"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.9.1175"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.518"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.6.1114"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.00320030103013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199408000-00015"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01772824"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.3.2309275"},{"key":"e_1_3_2_10_2","first-page":"414","volume":"22","year":"1991","unstructured":"Stehle G, Buss J, Heene DL. Noninfectious thrombosis of the superior sagittal sinus in a patient with iron deficiency anemia. Stroke. 1991;22:414. Letter.","journal-title":"Stroke"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198305000-00035"},{"key":"e_1_3_2_12_2","first-page":"318","volume":"55","year":"1988","unstructured":"Heller DS, Pervez NK, Kleinerman J. Fatal cerebrovascular thrombosis in a young woman: an unusual complication associated with hypochromic anemia and thrombocytosis following surgery. Mt Sinai J Med. 1988;55:318-320.","journal-title":"Mt Sinai J Med"},{"key":"e_1_3_2_13_2","first-page":"297","volume":"15","year":"1993","unstructured":"Saxena VK, Brands C, Crols R, Moens E, Marien P, de Deyn PP. Multiple cerebral infarctions in a young patient with secondary thrombocythemia due to iron deficiency anemia. 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