{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:22:32Z","timestamp":1768263752048,"version":"3.49.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            The purpose of this study was to evaluate the clinical usefulness of dynamic susceptibility contrast-enhanced MRI (DSC-MRI) in acute cerebral ischemia.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            During bolus injection of gadolinium-diethylenetriamine pentaacetic acid, a series of rapid T\n            <jats:sub>2<\/jats:sub>\n            *-weighted images was recorded from one slice. Concentration-time curves and images of regional cerebral blood volume (rCBV) were calculated from this data set. DSC-MRI, MR angiography, conventional spin-echo MRI (SE-MRI), and CT were performed in 11 patients within 6 hours after stroke onset and before thrombolytic or anticoagulant treatment was begun. A follow-up MRI examination was performed 24 to 48 hours after stroke onset.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            In 7 of 11 patients (group 1) with territorial infarcts of the middle (n=6) or posterior cerebral artery (n=1), DSC-MRI showed reduced rCBV in the affected territory before conventional SE-MRI displayed ischemic lesions. DSC-MRI was helpful to differentiate severely ischemic tissue from peri-infarct parenchyma. Partial reperfusion (n=3), unchanged reduction of rCBV (n=2), and progressive reduction of rCBV (n=2) were observed in the follow-up study. Normal DSC-MRI findings were present in 4 of 11 patients (group 2) with lacunar infarcts.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            DSC-MRI accomplished the detection of the ischemic territory in the very early stage (&lt;6 hours) before SE-MRI delivered unequivocal results. DSC-MRI might be helpful to discriminate completely ischemic tissue from potentially salvageable ischemic parenchyma at risk and may play an important role in stroke therapy and evaluation.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.6.1088","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1088-1093","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Assessment of Regional Cerebral Blood Volume in Acute Human Stroke by Use of Single-Slice Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging"],"prefix":"10.1161","volume":"27","author":[{"given":"Joachim","family":"Ro\u0308ther","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (J.R., W.N., A.S., M.H.) and Radiology (F.G.), Klinikum Mannheim, University of Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Gu\u0308ckel","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.R., W.N., A.S., M.H.) and Radiology (F.G.), Klinikum Mannheim, University of Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Neff","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.R., W.N., A.S., M.H.) and Radiology (F.G.), Klinikum Mannheim, University of Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.R., W.N., A.S., M.H.) and Radiology (F.G.), Klinikum Mannheim, University of Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hennerici","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (J.R., W.N., A.S., M.H.) and Radiology (F.G.), Klinikum Mannheim, University of Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.3.579"},{"key":"e_1_3_2_2_2","first-page":"621","volume":"12","year":"1991","unstructured":"Yuh WTC, Crain MR, Loes DJ, Greene GM, Ryals TJ, Sato Y. MR imaging of cerebral ischemia: findings in the first 24 hours. AJNR Am J Neuroradiol. 1991;12:621-629.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880030510"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.117"},{"key":"e_1_3_2_5_2","unstructured":"Warach S Wielopolski P Edelman RR. Identification and characterization of the ischemic penumbra of acute human stroke using echo planar diffusion and perfusion imaging. In: Abstracts of the 12th annual meeting of the Society of Magnetic Resonance in Medicine (SMRM); 1993:249. 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