{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:52Z","timestamp":1791291772311,"version":"4.1.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Cognitive deficits may significantly worsen the quality of life after stroke. Our aim was to determine the frequency of dementia in a consecutive series of previously nondemented patients between the ages of 40 and 79 years at 3 months after a first ischemic stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            All patients admitted to our department during an 18-month period who met the above criteria were visited and tested and underwent a CT scan 3 months after their stroke. Dementia was diagnosed according to criteria of the National Institute of Neurological Disorders and Stroke and AIREN, but cases with aphasia were not excluded.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Of 304 patients admitted for stroke, 146 were eligible for study. Eleven refused to participate, 25 were dead at 3 months, and 110 were tested. Fifteen patients were demented (13.6%; 95% confidence interval [CI], 7.8% to 21.5%), and six had severe isolated aphasia, neglect, or memory deficit (5.4%). Excluding patients with aphasia, 5.0% of cases showed dementia (95% CI, 1.6% to 11.3%). The frequency of dementia was 24.6% (95% CI, 14.5% to 37.3%), considering only patients with supratentorial lesions and with residual deficits of elementary functions (paresis, sensory deficits) at the time of examination. Demented patients had significantly more diabetes (\n            <jats:italic>P<\/jats:italic>\n            =.029), atrial fibrillation (\n            <jats:italic>P<\/jats:italic>\n            =.032), aphasia at entry (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001), large middle cerebral artery infarctions (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001), and a more severe neurological deficit at entry (\n            <jats:italic>P<\/jats:italic>\n            =.003) and at 3 months (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). At CT scan, demented patients had a larger mean volume of the recent lesion (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001) and more lesions in the frontal lobe (\n            <jats:italic>P<\/jats:italic>\n            =.041). An exploratory multivariate analysis selected age between 60 and 69 years (odds ratio [OR], 45.8; 95% CI, 2.9 to 726.0), diabetes (OR, 59.4; 95% CI, 4.3 to 821.0), aphasia (OR, 14.8; 95% CI, 2.0 to 111.0), a large middle cerebral artery infarction (OR, 30.0; 95% CI, 2.7 to 334.0), and lesions of the frontal lobe (OR, 9.8; 95% CI, 1.3 to 72.8) as significant independent correlates of poststroke dementia.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Dementia is relatively frequent after a clinical first stroke in persons younger than 80 years, and aphasia is very often associated with poststroke dementia. If aphasic patients are not considered, it may be necessary to screen a very large number of subjects to collect an adequate sample of demented cases.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.7.1205","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1205-1210","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":124,"title":["Dementia After First Stroke"],"prefix":"10.1161","volume":"27","author":[{"given":"Bruno","family":"Censori","sequence":"first","affiliation":[{"name":"the Neurologia 2 (B. Censori, M.C., L.C., B.G., T.P., M.C.S., A.M.) and the Neuroradiology Service (O.M., C.A., G.B.), Ospedali Riuniti, Bergamo, and the Epidemiologic Laboratory, IRCCS Ospedale Maggiore, Milan (B. 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