{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:07:34Z","timestamp":1761394054852},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,8]]},"abstract":"\n Background and Purpose<\/jats:italic>\n To elucidate the pathogenic role of vascular involvement such as mitochondrial angiopathy in patients with mitochondrial encephalomyopathy (MEM), we used the transcranial Doppler sonography (TCD) method to detect impairment of cerebrovascular CO\n 2<\/jats:sub>\n reactivity.\n <\/jats:p>\n \n Methods<\/jats:italic>\n The cerebral perfusion reserve in 13 MEM patients, including 6 with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) was studied by TCD for different CO\n 2<\/jats:sub>\n partial pressures. For the parameter of mean flow velocity, the mean spatial Doppler frequency (fm) was obtained from the right and left middle cerebral arteries and basilar artery under conditions of normocapnia, hypercapnia, and hypocapnia in cases in which hyperventilation was possible. By fitting the obtained fm and the end-tidal CO\n 2<\/jats:sub>\n partial pressure (P\n etco<\/jats:sc>\n 2<\/jats:sub>\n ) to the exponential formula fm=a\u00d7e\n \n (K\u00d7P\n etco<\/jats:sc>\n 2<\/jats:sub>\n )\n <\/jats:sup>\n , where a is the theoretical fm at a P\n etco<\/jats:sc>\n 2<\/jats:sub>\n of 0 mm\u2009Hg, the parameter K, an index of CO\n 2<\/jats:sub>\n reactivity, was calculated.\n <\/jats:p>\n \n Results<\/jats:italic>\n The K value was lower than control values at at least one site of the middle cerebral arteries and basilar artery of all patients with MELAS as well as the other MEM patients except for one patient with myoclonic epilepsy with ragged-red fiber and one with Kearns-Sayer syndrome.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n Our results suggest that there is a high incidence of impairment of cerebrovascular CO\n 2<\/jats:sub>\n reactivity in MEM patients. Moreover, the noninvasive TCD method was found useful for evaluation of cerebral hemodynamics in MEM patients.\n <\/jats:p>","DOI":"10.1161\/01.str.27.8.1350","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1350-1353","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["A Transcranial Doppler Ultrasonography Study of Cerebrovascular CO\n 2<\/sub>\n Reactivity in Mitochondrial Encephalomyopathy"],"prefix":"10.1161","volume":"27","author":[{"given":"Ryuhei","family":"Kodaka","sequence":"first","affiliation":[{"name":"the Department of Pediatrics (R.K., Y.I., T.N., S.O.) and the First Department of Internal Medicine (M.M.), Osaka University Medical School (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Itagaki","sequence":"additional","affiliation":[{"name":"the Department of Pediatrics (R.K., Y.I., T.N., S.O.) and the First Department of Internal Medicine (M.M.), Osaka University Medical School (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"the Department of Pediatrics (R.K., Y.I., T.N., S.O.) and the First Department of Internal Medicine (M.M.), Osaka University Medical School (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshisaburo","family":"Nagai","sequence":"additional","affiliation":[{"name":"the Department of Pediatrics (R.K., Y.I., T.N., S.O.) and the First Department of Internal Medicine (M.M.), Osaka University Medical School (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Okada","sequence":"additional","affiliation":[{"name":"the Department of Pediatrics (R.K., Y.I., T.N., S.O.) and the First Department of Internal Medicine (M.M.), Osaka University Medical School (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_2_1_2","DOI":"10.1016\/0022-510X(91)90280-K"},{"doi-asserted-by":"publisher","key":"e_1_3_2_2_2","DOI":"10.1002\/ana.410250611"},{"doi-asserted-by":"publisher","key":"e_1_3_2_3_2","DOI":"10.1007\/BF00688185"},{"doi-asserted-by":"publisher","key":"e_1_3_2_4_2","DOI":"10.1002\/ana.410290606"},{"doi-asserted-by":"publisher","key":"e_1_3_2_5_2","DOI":"10.1161\/str.24.2.8421833"},{"doi-asserted-by":"publisher","key":"e_1_3_2_6_2","DOI":"10.1097\/00004728-199101000-00010"},{"doi-asserted-by":"publisher","key":"e_1_3_2_7_2","DOI":"10.1007\/BF00344185"},{"doi-asserted-by":"publisher","key":"e_1_3_2_8_2","DOI":"10.1161\/str.25.9.8073472"},{"key":"e_1_3_2_9_2","first-page":"404","volume":"20","year":"1988","unstructured":"Watahiki Y, Tomiyama M, Nagata K, Shishido F, Kobayashi Y, Komatsu K, Goto A, Takada G. Positron emission tomographic study in patients with MELAS [in Japanese]. No To Hattatsu. 1988;20:404-411.","journal-title":"No To Hattatsu"},{"doi-asserted-by":"publisher","key":"e_1_3_2_10_2","DOI":"10.1016\/0022-510X(90)90168-M"},{"doi-asserted-by":"publisher","key":"e_1_3_2_11_2","DOI":"10.1007\/BF00380944"},{"doi-asserted-by":"publisher","key":"e_1_3_2_12_2","DOI":"10.1161\/str.24.5.8488521"},{"doi-asserted-by":"publisher","key":"e_1_3_2_13_2","DOI":"10.1161\/str.19.8.3135641"},{"doi-asserted-by":"publisher","key":"e_1_3_2_14_2","DOI":"10.1161\/str.26.11.2053"},{"doi-asserted-by":"publisher","key":"e_1_3_2_15_2","DOI":"10.1161\/str.7.5.960176"},{"doi-asserted-by":"publisher","key":"e_1_3_2_16_2","DOI":"10.1136\/bmj.1.5852.507"},{"doi-asserted-by":"publisher","key":"e_1_3_2_17_2","DOI":"10.1016\/0002-9343(53)90067-9"},{"doi-asserted-by":"crossref","unstructured":"Aaslid R. Transcranial Doppler examination techniques. In: Aaslid R ed. Transcranial Doppler Sonography. New York NY: Springer-Verlag; 1986:39-59.","key":"e_1_3_2_18_2","DOI":"10.1007\/978-3-7091-8864-4_4"},{"doi-asserted-by":"publisher","key":"e_1_3_2_19_2","DOI":"10.1016\/0301-5629(86)90016-5"},{"doi-asserted-by":"publisher","key":"e_1_3_2_20_2","DOI":"10.1038\/jcbfm.1984.54"},{"doi-asserted-by":"publisher","key":"e_1_3_2_21_2","DOI":"10.1152\/ajplegacy.1964.206.1.25"},{"doi-asserted-by":"publisher","key":"e_1_3_2_22_2","DOI":"10.1016\/0301-5629(88)90108-1"},{"key":"e_1_3_2_23_2","first-page":"596","volume":"232","year":"1983","unstructured":"Burki NK, Albert RK. Noninvasive monitoring of arterial blood gases. Chest. 1983;232:596-608.","journal-title":"Chest"},{"doi-asserted-by":"publisher","key":"e_1_3_2_24_2","DOI":"10.1016\/S0140-6736(66)92199-4"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.27.8.1350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:39:23Z","timestamp":1715553563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.27.8.1350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1161\/01.STR.27.8.1350"],"URL":"https:\/\/doi.org\/10.1161\/01.str.27.8.1350","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"type":"print","value":"0039-2499"},{"type":"electronic","value":"1524-4628"}],"subject":[],"published":{"date-parts":[[1996,8]]},"assertion":[{"value":"1996-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}