{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:20:24Z","timestamp":1770967224750,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            We have described sporadic cases of cerebral amyloid angiopathy with cerebral hemorrhage showing a low cystatin C level in the cerebrospinal fluid detected by enzyme-linked immunosorbent assay. Recently, several cases of leukoencephalopathy in patients with cerebral amyloid angiopathy have been reported. We describe a sporadic case of leukoencephalopathy with cystatin C-type cerebral amyloid angiopathy diagnosed during life by enzyme-linked immunosorbent assay.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Description<\/jats:italic>\n            A 74-year-old man who had suffered from progressive dementia for 3 years was admitted with right hemiparesis, dysarthria, and ataxia. MRI revealed pontine infarction and multiple lacunar state with leukoaraiosis. We suspected cystatin C-type cerebral amyloid angiopathy because of the low level of cystatin C in the cerebrospinal fluid. The patient died of sepsis 3 months later, and the presence of leukoencephalopathy with cerebral amyloid angiopathy was confirmed by autopsy. Immunohistological examination disclosed cystatin C and \u03b2-protein deposition in amyloid structures of the cortical cerebral arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Measurement of cystatin C in the cerebrospinal fluid by enzyme-linked immunosorbent assay is a useful method of diagnosing leukoencephalopathy related to sporadic cystatin C-type cerebral amyloid angiopathy.\n          <\/jats:p>","DOI":"10.1161\/01.str.27.8.1417","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1417-1419","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Leukoencephalopathy-Related Cerebral Amyloid Angiopathy With Cystatin C Deposition"],"prefix":"10.1161","volume":"27","author":[{"given":"Koichi","family":"Shimode","sequence":"first","affiliation":[{"name":"the Third Internal Medicine Department, Shimane Medical University (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotai","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"the Third Internal Medicine Department, Shimane Medical University (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Imaoka","sequence":"additional","affiliation":[{"name":"the Third Internal Medicine Department, Shimane Medical University (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Umegae","sequence":"additional","affiliation":[{"name":"the Third Internal Medicine Department, Shimane Medical University (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nagai","sequence":"additional","affiliation":[{"name":"the Third Internal Medicine Department, Shimane Medical University (Japan)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/95.2.387"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2974"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412133112406"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.7.1853405"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180110"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280108"},{"key":"e_1_3_2_8_2","first-page":"233","volume":"137","year":"1990","unstructured":"Vinters HV, Nishimura GS, Secor DL, Pardridge WM. Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brain of patients with Alzheimer's disease. Am J Pathol. 1990;137:233-240.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90124-4"},{"key":"e_1_3_2_10_2","first-page":"367","volume":"89","year":"1994","unstructured":"Hann J, Maat-Schieman MLC, van Duinen SG, Jensson O, Thorsteinsson L, Roos RAC. Co-localization of \u03b2\/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis. Acta Neurol Scand. 1994;89:367-371.","journal-title":"Acta Neurol Scand"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439760"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.27.8.1417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:38:59Z","timestamp":1715553539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.27.8.1417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1161\/01.STR.27.8.1417"],"URL":"https:\/\/doi.org\/10.1161\/01.str.27.8.1417","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]},"assertion":[{"value":"1995-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}