{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:44:47Z","timestamp":1774323887601,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            This study was designed to determine regional differences and age-related changes in the contribution of ATP-sensitive potassium (K\n            <jats:sub>ATP<\/jats:sub>\n            ) channels to vasodilator responses in the brain stem circulation in vivo.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Changes in diameter of the basilar artery (baseline diameter, 270\u00b15 \u03bcm [mean\u00b1SEM]), its large branch (112\u00b15 \u03bcm), and its small branch (49\u00b12 \u03bcm) in response to K\n            <jats:sub>ATP<\/jats:sub>\n            channel openers levcromakalim and Y-26763 were measured through a cranial window in anesthetized adult (4 to 6 months) and aged (24 to 26 months) Sprague-Dawley rats.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Topical application of levcromakalim and Y-26763 produced concentration-dependent vasodilation that was similar among the three vessel groups in adult rats. In aged rats, dilator responses of the branches, but not of the basilar artery, to the K\n            <jats:sub>ATP<\/jats:sub>\n            channel openers were smaller than those in adult rats (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). Glibenclamide, a selective K\n            <jats:sub>ATP<\/jats:sub>\n            channel blocker, almost abolished this vasodilation in both groups of rats. Vasodilator responses to sodium nitroprusside were preserved in aged rats.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In adult rats, there is no regional heterogeneity in vasodilator response to K\n            <jats:sub>ATP<\/jats:sub>\n            channel openers in the brain stem circulation in vivo. In aged rats, although K\n            <jats:sub>ATP<\/jats:sub>\n            channels are also functional in the brain stem circulation, dilator response of the microvessels but not of the large arteries to direct activation of K\n            <jats:sub>ATP<\/jats:sub>\n            channels is impaired.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.1.171","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Age-Related Changes in Response of Brain Stem Vessels to Opening of ATP-Sensitive Potassium Channels"],"prefix":"10.1161","volume":"28","author":[{"given":"Kazunori","family":"Toyoda","sequence":"first","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Takata","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuro","family":"Ibayashi","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiko","family":"Nagao","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Fujishima","sequence":"additional","affiliation":[{"name":"the Department of Internal Medicine, Kyushu Dental College, Kitakyushu (K.T., Y.T., M. Fujikawa); and the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka (K.F., S.I., T.K., T.N., M. Fujishima), Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2501869"},{"key":"e_1_3_2_2_2","first-page":"H8","volume":"264","year":"1993","unstructured":"Faraci FM, Heistad DD. Role of ATP-sensitive potassium channels in the basilar artery. Am J Physiol. 1993;264:H8-H13.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.74.5.8156623"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.9.1713"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.28.1.143"},{"key":"e_1_3_2_6_2","first-page":"H287","volume":"261","year":"1991","unstructured":"McCarron JG, Quayle JM, Halpern W, Nelson MT. Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries. Am J Physiol. 1991;261:H287-H291.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14209.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.78.2.238"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.1991.tb00422.x"},{"key":"e_1_3_2_10_2","first-page":"H1350","volume":"270","year":"1996","unstructured":"Toyoda K, Fujii K, Ibayashi S, Sadoshima S, Fujishima M. Changes in arterioles, arteries, and local perfusion of the brain stem during hemorrhagic hypotension. Am J Physiol. 1996;270:H1350-H1354.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.22.5.677"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.1.H152"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90172-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.1.8266368"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.7.3388460"},{"key":"e_1_3_2_16_2","first-page":"H1138","volume":"258","year":"1990","unstructured":"Mayhan WG, Faraci FM, Baumbach GL, Heistad DD. Effects of aging on responses of cerebral arterioles. Am J Physiol. 1990;258:H1138-H1143.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_17_2","first-page":"2459","volume":"25","year":"1994","unstructured":"Patern\u00f2 R, Faraci FM, Heistad DD. Age-related changes in release of endothelium-derived relaxing factor from the carotid artery. Stroke. 1994;25:2459-2462.","journal-title":"Stroke"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016566"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.69.3.1873864"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.2.2003286"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90499-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Haudenschild CC Prescott MF Chobanian AV. Aortic endothelial and subendothelial cells in experimental hypertension and aging. Hypertension. 1981;3(suppl I):I-148-I-153.","DOI":"10.1161\/01.HYP.3.3_Pt_2.I148"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/03610738008258359"},{"key":"e_1_3_2_24_2","first-page":"H851","volume":"264","year":"1993","unstructured":"Lartaud I, Bray-des-Boscs L, Chillon JM, Atkinson J, Capdeville-Atkinson C. In vivo cerebrovascular reactivity in Wistar and Fischer 344 rat strains during aging. Am J Physiol. 1993;264:H851-H858.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90053-6"},{"key":"e_1_3_2_26_2","first-page":"H11","volume":"266","year":"1994","unstructured":"Hong KW, Pyo KM, Lee WS, Yu SS, Rhim BY. Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation. Am J Physiol. 1994;266:H11-H16.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.15.10.1641"},{"key":"e_1_4_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.4.C799"},{"key":"e_1_4_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.9.1713"},{"key":"e_1_4_3_1_3_2","unstructured":"Faraci FM Sobey CG. Potassium channels and the cerebral circulation. Clin Exp Pharmacol Physiol. In press."},{"key":"e_1_4_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1262"},{"key":"e_1_4_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.4.H1498"},{"key":"e_1_4_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.9.1603"},{"key":"e_1_4_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.1.181"},{"key":"e_1_4_3_1_8_2","unstructured":"Faraci FM. Cerebral circulation during aging. In: Phillis JW ed. The Regulation of Cerebral Blood Flow. Boca Raton Fla: CRC Press; 1993:341-352."},{"key":"e_1_4_3_1_9_2","first-page":"H738","volume":"252","year":"1987","unstructured":"Faraci FM, Mayhan WG, Heistad DD. Segmental vascular responses to acute hypertension in cerebrum and brain stem. Am J Physiol.. 1987;252:H738-H742.","journal-title":"Am J Physiol."}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.28.1.171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:22:44Z","timestamp":1715552564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.28.1.171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1161\/01.STR.28.1.171"],"URL":"https:\/\/doi.org\/10.1161\/01.str.28.1.171","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1996-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}