{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:25:10Z","timestamp":1777119910005,"version":"3.51.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            An intronic polymorphism of presenilin-1 (PS-1), a gene responsible for early-onset familial Alzheimer\u2019s disease, has been reported to be associated with late-onset sporadic Alzheimer\u2019s disease. In a search for a genetic risk factor of sporadic cerebral amyloid angiopathy (CAA), we investigated the association of the polymorphism of PS-1 with CAA.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            The association between the severity of CAA and genotypes of a polymorphism in intron 8 of PS-1 was investigated in 137 autopsy cases of the elderly.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            A significant decrease of PS-1 2\/2 genotype frequency was associated with severe or moderate CAA.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            Our results suggest that PS-1 intronic polymorphism may be associated with the severity of CAA in the elderly.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.11.2219","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2219-2221","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Association of Presenilin-1 Polymorphism With Cerebral Amyloid Angiopathy in the Elderly"],"prefix":"10.1161","volume":"28","author":[{"given":"Masahito","family":"Yamada","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sodeyama","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Itoh","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Suematsu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Otomo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Psychiatry, University of Tokyo (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.2.3551211"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314080"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Itoh Y Yamada M Hayakawa M Otomo E Miyatake T. Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly. J Neurol Sci. 1993:116;135-141.","DOI":"10.1016\/0022-510X(93)90317-R"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380219"},{"key":"e_1_3_2_5_2","first-page":"2083","volume":"148","year":"1996","unstructured":"Premkumar DRD, Cohen DL, Hedera P, Friedland RP, Kalaria RN. 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