{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:40:35Z","timestamp":1791726035465,"version":"4.3.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy under general anesthesia for symptomatic or asymptomatic severe carotid stenosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Of 18 patients who underwent carotid endarterectomy with intra-arterial shunt, 2 (11.1%) developed an ischemic stroke. Of the other 94 patients, one suffered a nucleocapsular hemorrhage and 5 had cerebral ischemic complications. In these 5 patients, the duration of clamping was significantly longer (mean\u00b1SD, 16.4\u00b11.1 versus 12.7\u00b12.6 minutes;\n            <jats:italic>P<\/jats:italic>\n            =.0019), and the decrease of middle cerebral artery mean velocity on clamping was significantly greater (mean\u00b1SD, 56.4\u00b14.9% versus 28.8\u00b120.2%;\n            <jats:italic>P<\/jats:italic>\n            =.0031), while stump pressure was not significantly different. Microembolic signals were recorded in 70 patients (62.5%) and were not associated with cerebral ischemic complications. The 7 patients who developed cerebral ischemic complications had a significantly higher percentage of stenosis in the contralateral internal carotid artery (mean\u00b1SD, 82.0\u00b117.8% versus 29.3\u00b136.4%;\n            <jats:italic>P<\/jats:italic>\n            =.0018).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            The results of our study suggest that the major complications of carotid endarterectomy may be due to hemodynamic factors. Stump pressure alone is not a reliable indicator of hemodynamic changes that predict cerebral ischemia. Particulate microembolism may cause more subtle changes in cerebral parenchyma, but further studies are needed to clarify this point.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.12.2448","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2448-2452","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Role of Transcranial Doppler and Stump Pressure During Carotid Endarterectomy"],"prefix":"10.1161","volume":"28","author":[{"given":"Cinzia","family":"Finocchi","sequence":"first","affiliation":[{"name":"From the Department of Neuroscience and Neurological Rehabilitation, University of Genova (C.F., C.G., M. Del S.), and Department of Vascular Surgery, Ospedale di Imperia (T.C., C.B.) (Italy)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gandolfo","sequence":"additional","affiliation":[{"name":"From the Department of Neuroscience and Neurological Rehabilitation, University of Genova (C.F., C.G., M. Del S.), and Department of Vascular Surgery, Ospedale di Imperia (T.C., C.B.) (Italy)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Carissimi","sequence":"additional","affiliation":[{"name":"From the Department of Neuroscience and Neurological Rehabilitation, University of Genova (C.F., C.G., M. Del S.), and Department of Vascular Surgery, Ospedale di Imperia (T.C., C.B.) (Italy)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Massimo Del Sette","sequence":"additional","affiliation":[{"name":"From the Department of Neuroscience and Neurological Rehabilitation, University of Genova (C.F., C.G., M. Del S.), and Department of Vascular Surgery, Ospedale di Imperia (T.C., C.B.) (Italy)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Bertoglio","sequence":"additional","affiliation":[{"name":"From the Department of Neuroscience and Neurological Rehabilitation, University of Genova (C.F., C.G., M. Del S.), and Department of Vascular Surgery, Ospedale di Imperia (T.C., C.B.) 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New York NY; Raven Press Publishers; 1992:215\u2013230."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.10.1412581"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.20.6.2728057"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70096-6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.5.8304996"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81050-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.5.0778"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0967-2109(95)93881-O"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(05)80193-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800811009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.4.685"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.11.8236339"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.28.12.2448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:16:58Z","timestamp":1715552218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.28.12.2448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1161\/01.STR.28.12.2448"],"URL":"https:\/\/doi.org\/10.1161\/01.str.28.12.2448","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"1997-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}