{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:18:42Z","timestamp":1780636722395,"version":"3.54.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            To better understand the clinical pattern and further elucidate the risk factors and outcome in different subtypes of cerebral infarction (CI) of the Chinese in Taiwan, we analyzed the National Taiwan University Hospital Stroke Registry in 1995 and performed an ethnic comparison with similar data banks.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            From the National Taiwan University Hospital Stroke Registry in 1995, 676 patients (383 men and 293 women; mean age, 64.9 years; SD, 13.8 years; range, 1 to 98 years) with CI were recruited for this analysis. CI was classified into five subtypes based on clinical manifestations, ultrasonographic studies, and neuroimaging findings: large-artery atherosclerosis, lacunae, cardioembolism, other less common determined causes, and undetermined cause. Vascular risk factors, extracranial carotid artery atherosclerosis, and 30-day case-fatality rates were investigated in each subtype of CI.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Of all CI patients, 17%, 29%, 20%, 6%, and 29% were classified as large-artery atherosclerosis, lacunae, cardioembolism, other determined causes, and undetermined cause subtypes, respectively. The present results were compared with those from eight similar Western stroke registries. The relative incidence of lacunar CI in Chinese patients was more common, but large-artery atherosclerotic CI was less common than in whites. Hypertension was frequently seen in CI patients, especially in those with lacunae (85%) and large-artery atherosclerosis (69%). Patients with cardioembolism had a higher percentage of atrial fibrillation (69%), left ventricular hypertrophy, and ischemic heart disease than the other patients. Patients with large-artery atherosclerosis had more vascular risk factors, such as hypertension, diabetes mellitus, smoking, and carotid stenosis. Cardioembolic patients had higher case-fatality rates than other CI patients. Of the cardioembolic patients, 17.3% and 21.8% died within 30 days and during hospitalization, respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            The proportion of CI subtypes varied in different stroke registries. This may be partly due to applied classification criteria and racial-ethnic differences. Awareness of the risk factors and outcome in each subtype of stroke may afford further insights into the surveillance and treatment of cerebrovascular disease.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.12.2507","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2507-2512","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Subtypes of Ischemic Stroke"],"prefix":"10.1161","volume":"28","author":[{"given":"Ping-Keung","family":"Yip","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann-Shing","family":"Jeng","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti-Kai","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Chyuan","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zei-Shung","family":"Huang","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien-Kiat","family":"Ng","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (P-K.Y., J-S.J., Y-C.C, R-C.C.) and Internal Medicine (T-K.L., Z-S.H., S-K.N.), National Taiwan University Hospital, and En Chu Kong Hospital (T-K.L., R-C.C.), Taipei, Taiwan, Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","unstructured":"Mohr JP Sacco RL. Classification of ischemic stroke. In: Barnett HJM Stein BM Mohr JP Yatsu FM eds. Stroke: Pathophysiology Diagnosis and Management. New York NY: Churchill Livingstone Inc; 1992:271\u2013283."},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-O"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.9.3413804"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1540"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3057(96)80007-3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.6.8506547"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.4.650"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331977202300408"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.10.4.505476"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.1.54"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.1.14"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.4.3526645"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110399"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110393"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","unstructured":"Hier DB. Stroke data banks and stroke registries. In: Caplan LR eds. Brain Ischemia: Basic Concepts and Clinical Relevance. London England: Springer-Verlag Inc; 1995:355\u2013363.","DOI":"10.1007\/978-1-4471-2073-5_36"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.10.8091442"},{"key":"e_1_3_1_17_2","first-page":"194","volume":"3","year":"1994","unstructured":"Chung MY, Jeng JS, Yip PK, Hsu HC, Lee YT. Study on blood lipids, lipoproteins and apolipoproteins in different types of ischemic stroke. Acta Neurol Sin. 1994;3:194\u2013199.","journal-title":"Acta Neurol Sin"},{"key":"e_1_3_1_18_2","first-page":"29","volume":"4","year":"1995","unstructured":"Chen CC, Chung MY, Jeng JS, Yip PK, Hwang BS, Chang YC, Chen RC. A scoring system for evaluation of the extent of extracranial carotid atherosclerosis with B-mode imaging. Acta Neurol Sin. 1995;4:29\u201333.","journal-title":"Acta Neurol Sin"},{"key":"e_1_3_1_19_2","first-page":"144","volume":"3","year":"1995","unstructured":"Jeng JS, Yip PK, Chung MY, Chen CC, Hwang BS, Lin WH, Chang YC, Chen RC. Extracranial carotid artery atherosclerosis in 1014 physical check-up subjects (SCAN-III). J Med Ultrasound. 1995;3:144\u2013150.","journal-title":"J Med Ultrasound"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.1.46"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.61.722.1039"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1246"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.7.1046"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.11.1373"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.5.3363586"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.1021"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520090031012"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.8.754"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1983.tb04552.x"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.15.4.6464070"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.2.3961838"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1165"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250410"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410050055007"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.3.2309264"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.5.985"},{"key":"e_1_3_1_38_2","first-page":"204","volume":"9","year":"1986","unstructured":"Ryu SJ. The Chang Gung Stroke Registry: 1980. Chang Gung Med J. 1986;9:204\u2013216.","journal-title":"Chang Gung Med J"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.2.2003281"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830715)52:2<362::AID-CNCR2820520230>3.0.CO;2-V"},{"key":"e_1_3_1_41_2","unstructured":"Yu MC Henderson BE. Nasopharyngeal cancer. In: Schottenfeld D Fraumeni JF eds. Cancer Epidemiology and Prevention. 2nd ed. New York NY: Oxford University Press Inc; 1996:603\u2013618."},{"key":"e_1_3_1_42_2","first-page":"24","volume":"7","year":"1966","unstructured":"Yeh S. Some geographic aspects of most common diseases in Taiwan, part two. Int Pathol. 1966;7:24\u201328.","journal-title":"Int Pathol"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon199774260"},{"key":"e_1_3_1_44_2","unstructured":"Hung TP for the Study Group on Stroke. Prospective Survey and Registry of Stroke in Taiwan Area [in Chinese with English abstract]. Taipei Taiwan: Department of Health ROC; 1992."},{"key":"e_1_3_1_45_2","first-page":"S112","volume":"92","year":"1993","unstructured":"Chang SF, Su CL, Hung TP. Epidemiological study of cerebro-vascular disease in the Taiwan area: current status [in Chinese with English abstract]. J Formos Med Assoc.. 1993;92:S112\u2013S120.","journal-title":"J Formos Med Assoc."},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.9.1519279"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.10.1760"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.2.311"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.12.3201509"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.10.1926233"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.626"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.28.12.2507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:17:15Z","timestamp":1715552235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.28.12.2507"}},"subtitle":["A Hospital-Based Stroke Registry in Taiwan (SCAN-IV)"],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1161\/01.STR.28.12.2507"],"URL":"https:\/\/doi.org\/10.1161\/01.str.28.12.2507","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"1997-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}