{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:06:43Z","timestamp":1761059203140},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            We investigated whether cerebral microembolism as detected by transcranial Doppler ultrasonography (TCD) identifies patients at an increased risk for early, recurrent cerebral or retinal ischemic events.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            Records of consecutive patients examined during a 40-month period in the Neurovascular Laboratory were reviewed for the presence of cerebral microembolism. Of the original 302 patients, 229 with 310 arteries met inclusionary criteria. Follow-up information was obtained from the laboratory\u2019s database as well as the hospital records. Microembolus detection studies were performed on TC-2000 or TC-2020 instruments equipped with special software, and criteria established a priori were used for microembolus selection. TCD testing was performed a median interval of 9 days after the initial symptoms of cerebral ischemia. Severity of arterial stenosis was determined by cerebral angiography or noninvasive methods.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            Microembolic signals were detected more frequently in symptomatic (40\/140; 28.6%) than asymptomatic (21\/170; 12.4%) arteries (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). Ten recurrent ischemic events occurred during a median follow-up of 8 days after TCD examination, all in the territories of symptomatic arteries. Nine events occurred in the territories of microembolic signal\u2013positive arteries (9\/61; 14.8%) and one in the territory of a microembolic signal\u2013negative artery (1\/249; 0.4%) (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001). No association was detected in the subgroup with known cardiac lesions. Microembolic signals were more frequent in arteries with lesions causing 70% or more stenosis or occlusion (26\/99; 26.3%) than in those with a degree of stenosis less than 70% (17\/126; 13.5%) (\n            <jats:italic>P<\/jats:italic>\n            =.016).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            In this retrospective study, microembolic signals were more common in the territories of symptomatic arteries and particularly those with severely stenotic lesions. During a short follow-up, recurrent ischemic events were more common along the territories of arteries with TCD-detected microembolism and previous symptoms of cerebral or retinal ischemia.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.7.1314","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1314-1318","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Cerebral Microembolism and Early Recurrent Cerebral or Retinal Ischemic Events"],"prefix":"10.1161","volume":"28","author":[{"given":"Viken L.","family":"Babikian","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A. C.","family":"Wijman","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Hyde","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L.","family":"Cantelmo","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Winter","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Errol","family":"Baker","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val","family":"Pochay","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (V.L.B., C.A.C.W., E.B., V.P.), Radiology (C.H.), and Surgery (N.L.C.), Boston (Mass) University School of Medicine, and the Boston University School of Public Health (M.R.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"309","volume":"33","year":"1964","unstructured":"Marshall J. 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