{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:24:20Z","timestamp":1791307460315,"version":"4.3.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            Cerebral blood flow after cardiac arrest is reduced during the delayed hypoperfusion phase, while cerebral metabolic rate of oxygen returns to baseline values. Hypocapnia can induce cerebral ischemia in neurosurgical patients who already have reduced cerebral blood flow. The purpose of the present study was to determine whether comatose patients resuscitated from a cardiac arrest have a normal cerebrovascular reactivity to changes in Paco\n            <jats:sub>2<\/jats:sub>\n            and whether hypocapnia causes cerebral ischemia.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            We measured mean flow velocity (MFV) and pulsatility index (PI) in the middle cerebral artery, jugular bulb oxygen saturation (Sjb\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            ), and arterial-jugular lactate difference (AJLD) during normo-, hypo-, and hyperventilation in 10 comatose patients resuscitated from a cardiac arrest. The first measurements were made within 6 hours after cardiac arrest and repeated 6, 12, and 24 hours later.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            During hypoventilation we observed a significant decrease in PI and an increase in MFV and Sjb\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            . During hyperventilation PI and MFV did not change, but Sjb\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            showed a significant decrease. This was accompanied by an increase in AJLD, suggesting cerebral ischemia. In four patients the Sjb\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            decreased below the ischemic threshold of 55%.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            The cerebrovascular reactivity to changes in arterial carbon dioxide tension is preserved in comatose patients resuscitated from a cardiac arrest. Hyperventilation may induce cerebral ischemia in the postresuscitation period.\n          <\/jats:p>","DOI":"10.1161\/01.str.28.8.1569","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"1569-1573","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":140,"title":["Cerebrovascular Reactivity in Comatose Patients Resuscitated From a Cardiac Arrest"],"prefix":"10.1161","volume":"28","author":[{"given":"Gerba","family":"Buunk","sequence":"first","affiliation":[{"name":"From the Department of General Internal Medicine (Medical Intensive Care Unit), University Hospital Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G.","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"From the Department of General Internal Medicine (Medical Intensive Care Unit), University Hospital Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend E.","family":"Meinders","sequence":"additional","affiliation":[{"name":"From the Department of General Internal Medicine (Medical Intensive Care Unit), University Hospital Leiden, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.28.5.449"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.2.0241"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01456166"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.6.717"},{"key":"e_1_3_1_5_2","unstructured":"Abramson NS Ebmeyer U Ward KR Neumar RW. Bringing it all together: brain-oriented postresuscitation critical care. In: Paradis NA Halperin HR Nowak RM eds. Cardiac Arrest: The Science and Practice of Resuscitation Medicine. Baltimore Md: Williams & Wilkins; 1996:925."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(75)90071-4"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.6.1.21"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.10.5.116395"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.1.1731420"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316009"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/57.1.18"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.9.1519296"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709335"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.6.4.425"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07272.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199011000-00006"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.102.2.184"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1948.02310030021002"},{"key":"e_1_3_1_19_2","first-page":"38","volume":"34","year":"1994","unstructured":"Stocchetti N, Paparella A, Bridelli F, Bacchi M, Piazza P, Zuccoli P. Cerebral venous oxygen saturation studied with bilateral samples in the internal jugular veins. Neurosurgery. 1994;34:38-44.","journal-title":"Neurosurgery"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101994"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_3_1_22_2","unstructured":"Newell DW Aaslid R. Normal values and physiological variables. In: Newell DW Aaslid R eds. Transcranial Doppler. New York NY: Raven Press; 1992:41-48."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1990.9.7.403"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.8.899"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.13.6.6755813"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91712-X"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.8.3135641"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.5.1579964"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.5.3764963"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.1.0079"},{"key":"e_1_3_1_31_2","first-page":"S20","volume":"28","year":"1994","unstructured":"Ebmeyer U, Safar P, Radovsky A, Sharma C, Tanigawa K, Wang Y, Capone A, Xiao F, Bircher N, Stezoski W, Alexander H. Effective combination treatments for cerebral resuscitation from cardiac arrest in dogs: exploratory studies. Resuscitation. 1994;28:S20. Abstract.","journal-title":"Resuscitation"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.1.105"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.2.0212"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.28.8.1569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:35:21Z","timestamp":1715553321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.28.8.1569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.1161\/01.STR.28.8.1569"],"URL":"https:\/\/doi.org\/10.1161\/01.str.28.8.1569","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"1997-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}