{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:41:02Z","timestamp":1783690862235,"version":"3.55.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Occlusion of the central retinal artery (CRAO) causes a sudden decrease of monocular vision. Because early restoration of blood flow may improve outcome, we attempted to treat CRAO with selective intra-arterial fibrinolysis.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Intra-arterial fibrinolysis was performed within 6 hours after symptom onset in 17 patients with thromboembolic CRAO. Symptoms were painless, acute and severe decrease of vision. Urokinase (100 000 to 900 000 IU) was given through a microcatheter into the ophthalmic artery over 10 to 90 minutes. For comparison, the history and visual outcome of 15 control patients who did not receive fibrinolytics were evaluated. In both groups some of the patients underwent paracentesis and\/or received carboanhydrase inhibitors.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Patients who underwent fibrinolysis fared better than control patients (\n            <jats:italic>P<\/jats:italic>\n            =0.01). Three patients (17.6%) recovered completely after fibrinolysis and regained visual acuity of 20\/20 (n=2) to 25\/20 (n=1). Two additional patients (11.8%) showed a marked improvement to a visual acuity of 20\/30. In 6 patients (35.3%) vision improved slightly. They were able to count fingers, detect hand movements, or perceive light. In 6 patients (35.3%), fibrinolytic treatment was without effect. Among control patients, 1 patient (6.7%) showed partial, 4 patients (26.7%) minimal, and 10 (66.7%) no improvement of vision.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014A complete or marked improvement of visual acuity was achieved in one third of intra-arterial fibrinolysis patients but in none of the control patients. Intra-arterial fibrinolysis seems to have the potential to \u201clighten\u201d the spontaneously poor outcome of CRAO.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.10.2076","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2076-2079","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Selective Intra-Arterial Fibrinolysis of Acute Central Retinal Artery Occlusion"],"prefix":"10.1161","volume":"29","author":[{"given":"Johannes","family":"Weber","sequence":"first","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Remonda","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Koerner","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf W.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Sturzenegger","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ozdoba","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Koerner","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schroth","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (J.W., L.R., C.O., G.S.), Neurology (J.W., H.P.M., R.W.B., M.S.), and Ophthalmology (U.K., F.K.), Inselspital, University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.12.913"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76167-7"},{"key":"e_1_3_2_3_2","first-page":"240","volume":"31","year":"1991","unstructured":"Schumacher M, Schmidt D, Wakhloo AK. 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