{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:12:16Z","timestamp":1789542736108,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Asymptomatic microembolic signals (MES) can be demonstrated in patients with cerebral ischemia using transcranial Doppler (TCD) ultrasonographic monitoring of the middle cerebral artery. However, the clinical relevance of MES remains uncertain. The purpose of this study was to estimate the independent contribution of microembolism to the risk of early ischemic recurrence (EIR) in patients with stroke or transient ischemic attack (TIA) of presumed arterial origin.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014We studied the incidence of EIR in 73 consecutive patients with carotid stroke or TIA in whom TCD scanning of the symptomatic middle cerebral artery was performed within 7 days from the onset of symptoms. Patients with a potential cardiac source of embolism were excluded from the study.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Eight patients had EIR during a mean\u00b1SD follow-up of 10\u00b18 days. The incidence of EIR was 4.3 per 100 patient-days in patients with MES and only 0.5 per 100 patient-days in patients without MES. The presence of MES was a significant predictor of EIR after adjustment for the presence of carotid stenosis or aortic arch atheroma, antiplatelet therapy during follow-up, and other potential confounding variables (relative risk, 8.7; 95% confidence interval, 2 to 38.2;\n            <jats:italic>P<\/jats:italic>\n            =0.0015).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Microembolism is a significant independent predictor of EIR in patients with stroke or TIA of presumed arterial origin.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.10.2125","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2125-2128","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":103,"title":["Microembolic Signals and Risk of Early Recurrence in Patients With Stroke or Transient Ischemic Attack"],"prefix":"10.1161","volume":"29","author":[{"given":"Luc","family":"Valton","sequence":"first","affiliation":[{"name":"From the Department of Neurology (L.V, V.L., A.P.le T., G.G.) and the Department of Cardiology (P.M.), Rangueil Hospital, University of Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Larrue","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (L.V, V.L., A.P.le T., G.G.) and the Department of Cardiology (P.M.), Rangueil Hospital, University of Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pavy","family":"le Traon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (L.V, V.L., A.P.le T., G.G.) and the Department of Cardiology (P.M.), Rangueil Hospital, University of Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Massabuau","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (L.V, V.L., A.P.le T., G.G.) and the Department of Cardiology (P.M.), Rangueil Hospital, University of Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Ge\u0301raud","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (L.V, V.L., A.P.le T., G.G.) and the Department of Cardiology (P.M.), Rangueil Hospital, University of Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92916-P"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341902"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.3.2408197"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.5.1005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.4.1005"},{"key":"e_1_3_2_7_2","unstructured":"Valton L Larrue V Pavy le Traon A G\u00e9raud G B\u00e8s A. 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