{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:51:37Z","timestamp":1758477097279},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014Cholinesterases are found histochemically in the vessels affected with cerebral amyloid angiopathy (CAA). A gene for the K variant of butyrylcholinesterase (\n            <jats:italic>BCHE-K<\/jats:italic>\n            ) may be associated with late-onset Alzheimer\u2019s disease (AD). In search of genetic risk factors for CAA, we investigated the association of\n            <jats:italic>BCHE-K<\/jats:italic>\n            with CAA.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014The association between the severity of CAA and\n            <jats:italic>BCHE-K<\/jats:italic>\n            was investigated in 155 autopsy cases of the elderly, including 48 patients with AD.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014There was no significant association of\n            <jats:italic>BCHE-K<\/jats:italic>\n            with the severity of CAA in the total, AD, or non-AD cases. Status of the \u03b54 allele of apolipoprotein E gene did not influence the results.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Our results may suggest that\n            <jats:italic>BCHE-K<\/jats:italic>\n            is not a definitive risk factor for CAA in the elderly, although further study with larger samples is necessary to confirm this.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.12.2488","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"2488-2490","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Butyrylcholinesterase K Variant and Cerebral Amyloid Angiopathy"],"prefix":"10.1161","volume":"29","author":[{"given":"Masahito","family":"Yamada","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sodeyama","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Itoh","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Suematsu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Otomo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Tokyo Medical and Dental University (M.Y., N. Sodeyama, H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (N. Suematsu), Yokufukai Geriatric Hospital; and Department of Neuropathology, Tokyo Institute of Psychiatry (M.M.), Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.2.3551211"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314080"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90317-R"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380219"},{"key":"e_1_3_2_5_2","first-page":"2083","volume":"148","year":"1996","unstructured":"Premkumar DRD, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Apolipoprotein E \u03b54 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer\u2019s disease. 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