{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:25:19Z","timestamp":1777145119458,"version":"3.51.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>\n            <jats:italic>Background<\/jats:italic>\n            \u2014Neuropathological data are very scarce in systemic sclerosis and fail to demonstrate primary changes in the brains of such patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Case Descriptions<\/jats:italic>\n            \u2014A 41-year-old woman with CREST syndrome developed signs of dementia after an episode of severe dehydration and died two months later of septic shock. A 63-year-old woman with CREST syndrome and a history of two unexplained transient ischemic attacks had had balance disorders since age 62. She died of severe pulmonary hypertension. In both cases, the autopsy showed extensive wall calcification of small arteries and arterioles in the brain, primarily in the basal ganglia, and also in the frontal lobes and the cerebellar area in the second case. No known cause of cerebrovascular calcification was found in either patient.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusion<\/jats:italic>\n            \u2014The neuropathological findings in these two patients suggest that systemic sclerosis may induce primary vascular changes in the brain, of which calcification may be a marker.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.3.719","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"719-721","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Brain Involvement in Scleroderma"],"prefix":"10.1161","volume":"29","author":[{"given":"Emmanuel","family":"He\u0301ron","sequence":"first","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Fornes","sequence":"additional","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Rance","sequence":"additional","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Emmerich","sequence":"additional","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bayle","sequence":"additional","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Noe\u0308l","family":"Fiessinger","sequence":"additional","affiliation":[{"name":"From the Service de Me\u0301decine Vasculaire and the Centre Claude Bernard de Recherche sur les Maladies Vasculaires Pe\u0301riphe\u0301riques (E.H., A.R., J.E., J.-N.F.), the Service d\u2019Anatomopathologie (P.F.), and the Service de Psychiatrie (O.B.), Ho\u0302pital Broussais, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1955.03730360041004"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70306-9"},{"key":"e_1_3_1_3_2","first-page":"126","volume":"22","year":"1970","unstructured":"Gordon RM, Silverstein A. 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Oxford UK: Blackwell Scientific Publications Inc; 1996:346\u2013347."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.134.1.7350641"},{"key":"e_1_3_1_15_2","first-page":"218","volume":"166","year":"1996","unstructured":"Kanzaki S, Nukada O, Moriwake T, Seino Y. Intracranial calcification in patient with insulin-dependent diabetes mellitus. AJR Am J Roentgenol. 1996;166:218\u2013219.","journal-title":"Am J Roentgenol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500207"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.6.622"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530360094024"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.29.3.719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:37:57Z","timestamp":1715553477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.29.3.719"}},"subtitle":["Two Autopsy Cases"],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1161\/01.STR.29.3.719"],"URL":"https:\/\/doi.org\/10.1161\/01.str.29.3.719","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]},"assertion":[{"value":"1997-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}