{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:35:14Z","timestamp":1777480514143,"version":"3.51.4"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>\n            <jats:italic>Background and Purpose<\/jats:italic>\n            \u2014We sought to map early regional ischemia and infarction in patients with middle cerebral artery (MCA) stroke and compare them with final infarct size using advanced MRI techniques. MRI can now delineate very early infarction by diffusion-weighted imaging (DWI) and abnormal tissue perfusion by perfusion-weighted imaging (PWI).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            \u2014Seventeen patients seen within 12 hours of onset of MCA stroke had MR angiography, standard MRI, and PWI and DWI MRI. PWI maps were generated by analysis of the passage of intravenous contrast bolus through the brain. Cerebral blood volume (CBV) was determined after quantitative analysis of PWI data. Volumes of the initial DWI and PWI lesion were calculated and compared with a final infarct volume from a follow-up imaging study (CT scan or MRI).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            \u2014Group 1 (10 patients) had MCA stem (M1) occlusion by MR angiography. DWI lesion volumes were smaller than the volumes of CBV abnormality. In 7 patients the final stroke volume was larger or the same, and in 3 it was smaller than the initial CBV lesion. Group 2 (7 patients) had an open M1 on MR angiography with distal MCA stroke. In 6 group 2 patients, the initial DWI lesion matched the initial CBV abnormality and the final infarct.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            \u2014Most patients with M1 occlusion showed progression of infarction into the region of abnormal perfusion. In contrast, patients with open M1 had strokes consistent with distal branch occlusion and had maximal extent of injury on DWI at initial presentation. Application of these MRI techniques should improve definition of different acute stroke syndromes and facilitate clinical decision making.\n          <\/jats:p>","DOI":"10.1161\/01.str.29.5.939","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"939-943","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["Regional Ischemia and Ischemic Injury in Patients With Acute Middle Cerebral Artery Stroke as Defined by Early Diffusion-Weighted and Perfusion-Weighted MRI"],"prefix":"10.1161","volume":"29","author":[{"given":"Guy","family":"Rordorf","sequence":"first","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"Koroshetz","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Copen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Cramer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela W.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald F.","family":"Budzik","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee H.","family":"Schwamm","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Buonanno","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Gregory","family":"Sorensen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (G.R., W.J.K., S.C.C., L.H.S., F.B., A.G.S., G.G.) and Division of Neuroradiology (W.A.C., P.W.S., R.F.B.), Massachusetts General Hospital, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Mohr JP Gauthier J Hier D. Middle cerebral artery disease. In: Barnett HJM Mohr JP Stein BM Yatsu FM eds. Stroke: Pathophysiology Diagnosis and Management. 2nd ed. New York NY: Churchill Livingstone Inc; 1992:361\u2013418."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140218"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1717"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668784"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410506"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.6.0773"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.8.1866750"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.4.599"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Bogousslavsky J. Topographic patterns of cerebral infarcts: correlation with etiology. Cerebrovasc Dis. 1991;1(suppl 1):61\u201368.","DOI":"10.1159\/000108899"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.12.6.6272455"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Lassen N Fieschi C Lenzi G. Ischemic penumbra and neuronal death: comments on the therapeutic window in acute stroke with particular reference to thrombolytic therapy. Cerebrovasc Dis. 1991;1(suppl 1):32\u201335.","DOI":"10.1159\/000108878"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.29.5.939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:36:32Z","timestamp":1715553392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.29.5.939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1161\/01.STR.29.5.939"],"URL":"https:\/\/doi.org\/10.1161\/01.str.29.5.939","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"1997-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}